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Abstract #158724

Ximena Urrutia-Rojas, DrPH¹, Benjamin Willis, MD, MPH², Walter McConathy, PhD³, John Menchaca, MD⁴, Maria Jimenez, MD, MPH⁵, Sabitha Buttreddy, MS³, Sejong Bae, PhD⁶, Andras Lacko, PhD⁷, and Craig Spellman, PhD, DO³. (1) Social and Behavioral Sciences, UNT- HSC School of Public Health, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, 817-735-0325, xurrutia@hsc.unt.edu, (2) Internal Medicine, University of North TX Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, (3) Internal Medicine, UNT Health Science Center School of Medicne, 3500 Camp Bowie Blvd - PCC 313, Fort Worth, TX 76107, (4) Pediatrics, Cook’s Children’s Physician Network, Fort Worth, TX, 800 8th Ave. #124., Fort Worth Texas, TX 76104, (5) Dept of Social & Behavioral Sciences, UNT Health Science Center School of Public Health, 3500 Camp Bowie Blvd. EAD1-711A, Fort Worth, TX 76107, (6) Biostatistics, UNT Health Science Center School of Public Health, 3500 Camp Bowie Blvd - CBH 338, Forth Worth, TX 76107, (7) Molecular Biology & Immunology, UNT Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107

Purpose: assess the prevalence of abnormal glucose metabolism in Hispanic parents with acanthosis nigricans (AN+) children. Hypothesis: parents with AN+ children are at higher risk for diabetes. Methods: 258 Hispanic families with overweight children participating in a primary prevention of Type 2 diabetes (T2D) and cardiovascular diseases program were evaluated for metabolic and anthropometric parameters (fasting blood glucose, AN, and T2D). Criteria used: fasting impaired glucose (IFG), abnormal glucose (°Ý126 mg/dl), or prior diagnosis of T2D. Results: Of 343 parents screened (229 mothers/114 fathers), 90/30.0% of the parents with AN+ children showed abnormality of carbohydrate metabolism versus 17/18.3% of parents of AN- children (p=0.048). Among parents with AN+ children, 19.6% had IFG, 5.6% had abnormal glucose, and 4.8% had diagnosis of T2D. Conversely, 16.1% of parents of AN- children had IFG, 2.2% had abnormal glucose, and 0% had T2D. Almost one fifth (17.3%) of mothers with AN+ children had IFG compared to 7.1% with AN¨C children; 4.0% mothers with AN+ children had abnormal glucose compared to 1.8% with AN- children (p=0.028). Fathers of AN+ children showed higher prevalence of abnormal glucose levels compared to those with AN- children, however the difference was not statistically significant. Conclusions: Hispanic AN+ children have parents with a higher prevalence of carbohydrate metabolism abnormalities. Mothers with AN+ children may be affected more frequently with abnormal glucose metabolism. Having an AN+ child among Hispanics may need to be considered as an additional risk factor for focused screening for T2D.

Learning Objectives:

• 1. List at least 3 risk factors for type 2 diabetes (T2D) in adults
• 2. Define acanthosis nigricans (AN), fasting impaired glucose (IFG), abnormal glucose
• 3. Discuss screening tools for T2D

Keywords: Diabetes, Screening

Presenting author's disclosure statement:

Any relevant financial relationships? No
Any institutionally-contracted trials related to this submission?

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.