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Abstract #160535

Suzanne M. Dolwick Grieb, MSPH¹, Ryan P. Theis, MPH¹, Dan Benardot, PhD, DHC, RD², Tariq Siddiqui, MD³, Deborah Burr, PhD¹, John Christopher, PhD⁴, and Nabih Asal, PhD¹. (1) College of Public Health and Health Professions, University of Florida, PO Box 100231, Room 3110, 101 S. Newell Dr., Gainesville, FL 32610-0231, 352-378-0956, sdolwick@ufl.edu, (2) College of Health and Human Sciences, Georgia State University, University Plaza, Atlanta, GA 30303, (3) Department of Medicine, Division of Hematology/Oncology, University of Florida, Acedemic Research Building, PO Box 100277, Gainesville, FL 32610-0277, (4) College of Public Health and Health Professionals, University of Florida, PO Box 100231, Room 3110, 101 S. Newell Dr., Gainesville, FL 32610-0231

Background: Diet has been associated with renal cell carcinoma (RCC), however the specific food types involved remain controversial. The present study used a case-control design to evaluate the role of dietary patterns on RCC risk. Methods: Incident cases of RCC were identified from the Florida Cancer Data System, and population controls were identified from random-digit dialing. In-person interviews were conducted among 335 cases and 337 controls using a standardized food questionnaire. Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI). All analyses were controlled for age, sex, race, smoking, body mass index (BMI) and income. Results: Significant associations were found between various food items and RCC. Among the total population, eating four or more servings of vegetables daily significantly reduced risk of RCC (OR: 0.60; 95% CI: 0.43, 0.82). Eating red meat once a week or more significantly increased RCC risk (OR: 1.80, 95% CI: 1.24, 2.60). Consumption of three or more servings of fat daily increased RCC risk by 70% (OR: 1.70, 95% CI: 1.19, 2.43). Significant direct trends in risk were observed among many of food items, including various meats, vegetables, grains and fats. Results varied by sex and race. Discussion: Continued increases in incidence of RCC cannot fully be explained by better detection, especially among African-Americans. The findings of this study provide further evidence of dietary correlates of RCC. Specifically, a diet low in vegetables and high in red meat and fat consumption may have an unfavorable role on RCC.

Learning Objectives:

• Describe dietary patterns associated with increased risk of renal cell carcinoma (kidney cancer)
• List food items associated with renal cell carcinoma (kidney cancer)
• Prioritize needs for future research regarding dietary factors and renal cell carcinoma (kidney cancer)

Keywords: Cancer, Nutrition

Presenting author's disclosure statement:

Any relevant financial relationships? No
Any institutionally-contracted trials related to this submission?

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.