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Abstract #162638

Miguel Mujica-Baella, MD¹, Ryan P. Theis, MPH¹, Suzanne M. Dolwick Grieb, MSPH¹, Tariq Siddiqui, MD², Deborah Burr, PhD¹, John Christopher, PhD¹, and Nabih Asal, PhD¹. (1) College of Public Health and Health Professions, University of Florida, PO Box 100231, Room 3110, 101 S. Newell Dr., Gainesville, FL 32610-0231, 787-504-5608, mmujica@ufl.edu, (2) Department of Medicine, Division of Hematology/Oncology, University of Florida, Acedemic Research Building, PO Box 100277, Gainesville, FL 32610-0277

Background: The effects of various beverages on the incidence of renal cell carcinoma (RCC) remain inconclusive, while recent studies have suspected protective effects for high fluid intake. This study evaluates the role of common beverages and fluid intake using a case-control design. Methods: Incident cases (n = 335) were identified from Florida hospital records and the state cancer registry, and population controls (n = 337) were identified from random-digit dialing. Interviews assessed one-year intake of coffee, tea, soda, juice, milk, beer and wine. Odds ratios and 95% confidence intervals were calculated using logistic regression, controlled for age, sex, race, smoking, and BMI. Results: A significant protective trend was found for coffee consumption (all types) when measured in lifetime cup-years (Wald χ2 = 5.603, p = 0.018). Drinking four cups of coffee per day for approximately 40 years significantly reduced risk for RCC (OR: 0.35; 95% CI: 0.20, 0.62), an association that was stronger among men and whites. Controls were more likely than cases to consume wine once a week or more, although this association was only marginally significant among whites (OR: 0.68; 95% CI: 0.45, 1.02). Consuming 48 ounces or more of fluid per day was associated with reduced risk only among men (OR: 0.63; 95% CI: 0.39, 1.00). No associations were found for tea or diet sodas. Conclusion: Heavy coffee consumption and overall fluid intake may reduce risk for RCC by decreasing the concentration of carcinogens in contact with renal cells. Gender-specific differences in these associations warrant further study.

Learning Objectives:

• Assess the role of coffee and alcohol consumption in the etiology of renal cell cancer.
• Identify the potential mechanisms by which total fluid intake reduces the risk for renal cell cancer.
• Assess the effects of gender and race on the association between beverage consumption and renal cell cancer.

Keywords: Cancer, Food and Nutrition

Presenting author's disclosure statement:

Any relevant financial relationships? No
Any institutionally-contracted trials related to this submission?

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.