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Abstract #162708

Nabih Asal, PhD¹, Ryan P. Theis, MPH¹, Suzanne M. Dolwick Grieb, MSPH¹, Tariq Siddiqui, MD², Deborah Burr, PhD¹, and John Christopher, PhD¹. (1) College of Public Health and Health Professions, University of Florida, PO Box 100231, Room 3110, 101 S. Newell Dr., Gainesville, FL 32610-0231, 352-273-5363, asal@phhp.ufl.edu, (2) Department of Medicine, Division of Hematology/Oncology, University of Florida, Acedemic Research Building, PO Box 100277, Gainesville, FL 32610-0277

Background: Tobacco use is an established risk factor for renal cell carcinoma (RCC), although little is known regarding the influence of environmental tobacco smoke (ETS). This study assesses the role of tobacco and ETS on RCC incidence using a case-control design. Methods: Incident cases (n = 335) were identified from Florida hospital records and the state cancer registry, and population controls (n = 337) were identified from random-digit dialing. Interviews assessed lifetime consumption of cigarettes and exposure to ETS at home, work, and public/private spaces. Odds ratios and 95% confidence intervals were calculated using logistic regression, controlled for age, sex, race, and BMI. Results: A significant association was found between pack-years and RCC (Wald χ2 = 5.987, p = 0.014). Cases were more likely to have smoked 20 pack-years (OR: 1.48, 95% CI: 1.06-2.07), an association that remained significant only for whites in stratified analyses. A significant protective effect was found for smoking cessation among ex-smokers (Wald χ2 = 17.468, p = 0.000), particularly for 15+ years of cessation (OR: 0.31, 95% CI: 0.18-0.55). Cases were more likely to report home ETS exposure of 20+ years (OR: 1.67; 95% CI: 1.20-2.32), an association that was significant for all groups on stratified analyses by gender and race. Work ETS exposure was significantly associated with RCC only among women, at 15+ years (OR: 1.98; 95% CI: 1.16, 3.38). Conclusion: These findings confirm the known association between tobacco use and RCC and establish a potential etiologic role for ETS, particularly in the home.

Learning Objectives:

• Evaluate the role of cigarette smoking on the etiology of renal cell carcinoma, using a measure that accounts for cessation periods and variation in use across age-decades.
• Describe the association between environmental tobacco smoke and renal cell carcinoma.
• Assess differences in renal cell cancer risk according to context of environmental tobacco smoke exposure, gender and race.

Keywords: Cancer, Tobacco

Presenting author's disclosure statement:

Any relevant financial relationships? No
Any institutionally-contracted trials related to this submission?

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.