In Taiwan, school children regularly receive proteinuria screen for reanal disease prevention, in addition to for glucosuria screen for diabetes prevention. To identify factors associated with childhood proteinuria, we conducted a case-control study using data obtained from mass urine screening for school children, conducted each semester (average N=3.5 millions) from 1992 to 1997. Children with positive result(s) from the mass screen received a follow-up examination. Positive subjects received further confirmation examinations including a third urine test, and measures of cholesterol, plasma glucose and blood pressure. Cases were subjects who tested positive for proteinuria on the third urine test (n=4478 boys and 5158 girls). Compared with negative subjects in the confirmation test (n=31828 boys and 54625 girls), multivariate logistic regression analysis showed boys were 2.2 times more likely than girls to have proteinuria, childhood proteinuria was significantly associated with hypertension (odds ratio (OR)=2.5, 95% confidence interval (CI)=1.9-3.4), hypercholesterolemia (OR=152.5, 95% CI=85.5-272.0) but not with an elevated body mass index (>25kg/m2, OR=0.50, 95% CI=0.3-0.7). Children with proteinuria were also 6.4 times more likely to be diagnosed with renal disease in a subsequent medical consultation. In conclusion, children of positive proteinuria tests with hypertension and/or hypercholesterolemia may predispose to a childhood renal disease. (Supported by Taiwan Provincial Department of Health).
Learning Objectives: To assess risk factors associated with the development of childhood renal disease for children with proteinuria found in mass screening program.
Keywords: Child Health, Screening
Presenting author's disclosure statement:
Organization/institution whose products or services will be discussed: None
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.