4051.0: Tuesday, October 23, 2001 - Board 3

Abstract #28213

Impact of Medical Nutrition Therapy on Nutritional Indices of Patients with AIDS-Related Wasting

Wendy L. Johnson-Taylor, PhD1, Charles M. van der Horst, MD2, Boyd R. Switzer, PhD3, Pamela S. Haines, DrPH, RD4, Janice M. Dodds3, and Andrea K. Biddle, PhD, MPH5. (1) Public Health Program, Morgan State University, 1700 East Cold Spring Lane, Jenkins Hall, Room 343, Baltimore, MD 21251, 443-885-4015, wjohnsonta@home.com, (2) School of Medicine, University of North Carolina @ Chapel Hill, 547 Burnett-Womack Building CB#7400, Chapel Hill, NC 27514, (3) Nutrition, University of North Carolina @ Chapel Hill, 2207 Mcgavran-Greenberg Building, CB#7400, Chapel Hill, NC 27514, (4) School of Public Health, Department of Nutrition, University of North Carolina at Chapel Hill, CB #7400, Chapel Hill, NC 27599, (5) Department of Health Policy and Administration, University of North Carolina at Chapel Hill, CB#7400, Chapel Hill, NC 27599-7400

The Impact of Medical Nutrition Therapy on Nutritional Indices of Patients with AIDS-Related Wasting

Abstract:

Objectives: To determine the impact of nutrition intervention on nutritional indices within patients with AIDS-related wasting.

Methods: Thirty-seven patients were randomized to either an intervention or control group and followed for 4 months. The intervention group received an oral liquid nutrition supplement that had medium chain triglycerides as 85% of the fat source; a daily multi-vitamin/mineral supplement, and nutrition education that focused on food safety, nutrient dense foods and sick day eating guidelines. Measures of weight, height, lean body mass, fat mass, protein and calorie intakes were taken at baseline and month 4.

Outcome measures: Differences from baseline to month 4 were analyzed using ANOVA. Comparisons were made within and between the groups.

Results: Patients in the intervention group maintained lean body mass, maintained weight and fat mass. The control group lost lean body mass and maintained weight and fat mass. The loss of lean body mass approached statistical significance at p=0.06. Patients who received the intervention and were prescribed protease inhibitors had statistically significant gains in lean body mass at p=0.03. The consumption of the formula significantly increased the protein and caloric intake of the intervention group.

Conclusions: The nutrition intervention used in the study is effective at delaying the progression of wasting and may reverse wasting if used concurrently with protease inhibitors.

Learning Objectives: At the conclusion of the session the participant (learner) in this session will be able to: 1)Evaluate the impact of nutriton intervention on AIDS-related wasting 2) Discuss the benefits of nutrition as an integral component of treatment for AIDS-related wasting 3) Develop a standard of practice for treatment of AIDS-related wasting that includes nutrition services

Keywords: Nutrition, Intervention

Presenting author's disclosure statement:
Organization/institution whose products or services will be discussed: Mead Johnson Nutritionals Sundown Vitamins
Disclosure not received
Relationship: Not Received.

The 129th Annual Meeting of APHA