Increasing primary cancer incidence due to early detection and improved cancer treatment has increased the population at risk for developing a second primary cancer. The success of early cancer diagnosis, treatment, and survival is somewhat offset by the survivors' risk of developing a second primary cancer due to shared risk factors, genetic predisposition, and treatment effects.To examine the incidence of second malignancies in United States, the age-adjusted and sex-stratified incidence of SEER registrants from 1975 through 1996 was examined. Age-adjusted rates of primary malignancies have been increasing over the last 22 years. The average increase in first malignancies among males was 2.9 per 100,000 person-years per year and the average female increase was 41.6 per 100,000 person-years per year. After controlling for age and year of diagnosis, Cox models indicate that 50% of male and 50% females SEER registrants will develop a second primary in 6 and 9 years, respectively. Further analysis of the relationship between specific treatment effects and modifiable risk for the prevention of second primary cancers is needed.
Learning Objectives: Investigate the relationship between primary and secondary malignancies.
Keywords: Cancer Screening,
Presenting author's disclosure statement:
Organization/institution whose products or services will be discussed: Surveillance, Epidemiology, and End Results (SEER) database
Disclosure not received
Relationship: Not Received.