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The 130th Annual Meeting of APHA |
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The 130th Annual Meeting of APHA |
George A. Kelley, DA and Kristi S. Kelley, MEd. School of Medicine, Department of Community Medicine, West Virginia University, Robert C. Byrd Health Sciences Center, 3316 HSC(S), Morgantown, WV 26506-9190, 304-293-1500, gkelley@hsc.wvu.edu
PURPOSE: The purpose of this study was to conduct a meta-analysis of individual patient data (IPD) in order to examine the effects of exercise on lumbar spine bone mineral density (BMD) in postmenopausal women. METHODS: IPD were requested from a previously developed database of summary means from randomized and nonrandomized trials dealing with the effects of exercise on BMD. Two-way analysis of variance (ANOVA) tests with pairwise comparisons (p < 0.05) and 95% confidence intervals (CIs) were used to determine the statistical significance for changes in lumbar spine BMD. RESULTS: Across 13 trials that included 699 subjects (355 exercise, 344 control), a statistically significant interaction was found between test and group (F=15.232, p=0.000). Pairwise comparisons (Bonferroni t-tests) revealed a statistically significant increase in final minus initial BMD for the exercise group (mean +/- SD=0.005 +/- 0.043 g/cm2, t=2.46, p=0.014, 95% CI=0.001 to 0.009) and a statistically significant decrease in final minus initial BMD for the control group (mean +/- SD=-0.007 +/- 0.045 g/cm2, t=-3.051, p=0.002, 95% CI=-0.012 to –0.002). Changes were equivalent to an approximate 2% benefit in lumbar spine BMD (exercise, +1%, control, -1%). CONCLUSIONS: The results of this IPD meta-analysis suggest that exercise helps to improve and maintain lumbar spine BMD in postmenopausal women.
Learning Objectives:
Keywords: Exercise, Women
Presenting author's disclosure statement:
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.