 |
The 130th Annual Meeting of APHA |
|
The 130th Annual Meeting of APHA |
Karen Goodman, PhD1, Kathleen M O'Rourke, PhD, MPH2, R Sue McPherson, PhD1, Constance Wang1, Thomas Redlinger3, Armando Campos1, and Manuel de la Rosa4. (1) University of Texas Houston School of Public Health, P.O. Box 20186, Houston, TX 77225, (2) Biometry and Epidemiology, Medical University of South Carolina, 135 Rutledge Ave, Suite 1134, Charleston, SC 29425, (3) Biology, University of Texas, El Paso, 500 West University Avenue, El Paso, TX 79968, (4) Texas Tech University Health Science Center, 4800 Alberta Avenue, El Paso, TX 79905
Helicobacter pylori infection occurs frequently in early childhood; persistence leads to chronic digestive diseases in adults. The Pasitos Cohort Study follows children from El Paso, Texas and Ciudad Juarez, Mexico at 6-month intervals to identify predictors of acquisition and persistence. Pregnant women were recruited from El Paso WIC clinics and Mexican Social Security Institute maternal-child clinics in Juarez from April 1998 to October 2000. The seroprevalence of H.pylori at baseline was 74% in Juarez mothers and 56% in El Paso mothers. Follow-up of children is ongoing. Active H.pylori infection is detected in children by the 13C-urea breath test; results are corrected for body-size-dependent metabolic variation using Klein’s method. This analysis presents results for two years of follow-up; 350, 295, 196, and 153 infants had breath tests around 6, 12, 18, and 24 months of age, respectively; H.pylori prevalence was 0.07 [95% confidence interval (CI), 0.05-0.10], 0.14, [0.11-0.19], 0.17 [0.12-0.23], and 0.20 [0.14-0.27] for these four age groups, respectively. The total follow-up time was 6181 person-months; 108 infants had one or more positive breath tests, thus the incidence rate of first detectable infections was 0.21/year [95% CI, 0.17-0.25]. Incidence rates for subgroups: Juarez infants, 44 / 2260 person-months=0.23/year [0.16-0.30]; El Paso infants, 64 / 3921 person-months=0.20/year [0.15-0.24]; boys, 49 / 2976 person-months=0.20/year [0.14-0.25]; girls, 59 / 3205 person-months=0.22/year [0.16-0.28]; first year of age, 66 / 4243 person-months=0.19/year [0.14-0.23]; second year of age, 31 / 1340 person-months=0.28/year [0.18-0.38].
Learning Objectives:
Keywords: Helicobactor pylori, Epidemiology
Presenting author's disclosure statement:
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.