This presentation outlines the final results of an NCI funded study (N=500) that surveyed callers of the Cancer Information Service (CIS) Atlantic Region who were newly diagnosed with cancer to understand their use of Internet health information and to understand the relationship of this use to both patient behavior and perceived self-efficacy.  Comparing Direct users (people who accessed Internet health information themselves) to Indirect users (people who received Internet health information obtained by friends or family) and Non-users (people who had not accessed Internet health information), callers were accrued when they called the CIS for cancer information and then surveyed by phone six to eight weeks later.  Significant findings include a major shift in Internet user category, with over 25% of Indirect users and Non-users changing categories.  New data indicate that having cancer as well as support of friends and families were the key reasons people sought out Internet information.  In addition, Direct users were found to ask significantly more questions of their physicians, indicate their relationships with their physicians were “partnerships” as well as make question lists before an appointment.  There were also significant relationships between a number of self efficacy measures, including maintaining independence, indicating that those using Internet health information felt more confident in being able to deal with their illness.  This study has great potential in helping public health professionals begin to understand the complex relationships between new technology with what is already known about the use of health communication as a tool for behavior change.