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The 130th Annual Meeting of APHA |
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The 130th Annual Meeting of APHA |
Michiyo Hashimoto, PhD1, Midori Nishiyama, MD, PhD1, Masami Orui, MD, PhD2, and Takahiro Usami, PhD1. (1) Department of Public Health Sciences, Dokkyo University School of Medicine, Mibu-machi, Shimotsuga-gun, Tochigi, 321-0293, Japan, +81-282-87-2133, michiyoh@dokkyomed.ac.jp, (2) Department of Health Care, Dokkyo University School of Medicine, Mibu-machi, Shimotsuga-gun, Tochigi, 321-0293, Japan
Diabetic patients in Japan have been increasing every year, and it is a major public health concern to identify the risk group of diabetes and develop an effective strategy for primary prevention. 9,725 subjects who received a medical screening between 1992 and 2001 were divided into two groups based on the WHO criteria; the normal group (N=2,353; having normal blood glucose levels for two consecutive years) and the borderline group (N=434; having normal blood glucose levels at the baseline and the borderline-type the following year). As a result, significant odds ratios were found in HDL-C for subjects 40 years and younger, body mass index, ƒÁ-GTP, HDL-C, and liver steatosis for those 41-50 years, body mass index, DBP, AST, ALT, uric acid, liver steatosis, fatty liver, and alcohol habit for those 51-60 years, and being male for those 61 years and older. Abnormal triglyceride and 60-min. oral glucose tolerance test (OGTT) values at the baseline were significant across all 4 age groups. Multiple logistic regression analyses revealed that significant predictors of borderline diabetes were high triglyceride for 40 and younger, low HDL-C, high ƒÁ-GTP, and liver steatosis for 41-50 years, high uric acid, liver steatosis, fatty liver, and alcohol habit for 51-60 years, and high SBP for 61 years and older. In conclusion, age-specific risk factors for borderline diabetes were proposed in this study. It was suggested that 60-min. OGTT was effective to predict borderline diabetes a year in advance while it is not currently used as diagnostic criteria in Japan.
Learning Objectives:
Keywords: Diabetes, Risk Factors
Presenting author's disclosure statement:
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.