The 130th Annual Meeting of APHA

Abstract #46498

Ashish V Joshi, MS¹, David Day, PhD², Teresa J Lubowski, Pharm D², Mayur Amonkar, PhD³, and Ambarish Ambegaonkar, PhD². (1) Department of Pharmaceutical Systems and Policy, Pfizer/West Virginia University, P.O. Box 9510, Room 1122B, Robert C. Byrd Health Sciences Center, Morgantown, WV 26506-9510, 3046852100, ajoshi@hsc.wvu.edu, (2) Clinical Applications, Pfizer Inc., 150 E. 42nd st., MS # 150-37-03, New York, NY 10017, (3) Pharmaceutical Systems and Policy, West Virginia University School of Pharmacy, PO Box 9510, Morgantown, WV 26506-9510

Objective: This study examined the impact of BMI category on SBP, high-density lipoprotein (HDL) and total cholesterol (TC).

Methods: Voluntary coronary heart disease (CHD) risk screenings were conducted in 14 states. A mobile screening unit and team were used to collect data. Respondents were classified as per WHO guidelines as non-overweight (BMI <=25); overweight (BMI > 25 and <=30); obese (BMI > 30 and <=35); and morbidly obese (BMI > 35). Multiple regression analyses were used to measure the impact of BMI on SBP, HDL and TC after adjusting for age, race, gender, smoking, medications for hypertension and hyperlipidemia, diabetes and/or CHD event.

Results: Of the 9,845 screened, 36% were overweight, 17.2 % were obese and 8.1% were morbidly obese. Diabetes and prior CHD event were reported in 4.5% and 11% of the respondents respectively. Compared to non-overweight respondents, SBP increased by 13.2 mmHg for morbidly obese (p<0.001); by 9.1 mmHg for obese (p<0.001) and by 5.0 mmHg (p<0.001) for overweight respondents respectively. TC was 5.7 mg/dL higher in obese (p<0.01), and 5.9 mg/dL higher in overweight respondents (p<0.001) as compared to non-overweight respondents. As compared to non-obese respondents, HDL was 9.3 mg/dL lower in morbidly obese (p<0.001), 6.6 mg/dL lower in obese (p<0.001), and 3.7 mg/dL lower in overweight respondents (p<0.001). Framingham 10-year CHD risk scores increased by 0.3 units per unit increase in BMI category.

Conclusions: Our results demonstrate a significant impact of increasing BMI category on the CHD risk factors of SBP and HDL.

Learning Objectives:

• Assess the impact of BMI obesity categories on systolic blood pressure, high density cholesterol and total cholesterol after controlling for other coronary heart disease risk specific variables.
• Evaluate the relationship between the calculated Framingham coronary heart disease risk estimate and the various categories of obesity.

Keywords: Obesity, Risk Factors

Presenting author's disclosure statement:
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.