 |
The 130th Annual Meeting of APHA |
|
The 130th Annual Meeting of APHA |
Mary A. Fox, PhD, MPH and Linda Abbott, PhD. Office of Risk Assessment and Cost Benefit Analysis, US Department of Agriculture, 1400 Independence Avenue, SW, Ag Code: 3811, Room 5248, Washington, DC 20250, 202-720-9000, mfox@oce.usda.gov
US EPA's precedent setting cumulative risk assessment for the organo-phosphate pesticides revolutionizes health-based regulation of pesticides and the field of quantitative risk assessment. US Department of Agriculture, in cooperation with US EPA, conducted sensitivity analyses on the dietary portion of the risk assessment to identify those components of the model that most contribute to high-end exposure estimates, such as consumers, diets, commodities, pesticide residues, and/or model settings. USDA duplicated the US EPA assessment and then conducted a number of replicate assessments varying input parameters and the number of iterations for the Monte Carlo model. For each run of the model the records in the output at the 99.9th percentile were retained. Examination of these records identified potential risk driver commodities, residues, and consumers. In the population of 1-2 year olds in a USDA replicate assessment, two consumers' diets make up 45% of the records for one of the top five commodities. Varying the seed value yields exposure estimates between 0.0014 and 0.0017 mg/kg BW/day and margins of exposure between 45 and 56, as compared to US EPA's result of 0.0016 (MOE=51). Removal of the commodity contributing most to high exposures in 1-2 year olds increases the MOE to 56 from 51. Exposure estimates may be influenced by data inputs and by the science-policy decisions that bridge data gaps. Results to date suggest inputs have little impact on exposure estimates and risk. Therefore the Agency's science policy decisions will determine the regulatory fate of the OP pesticides.
Learning Objectives:
Keywords: Children's Health, Risk Assessment
Presenting author's disclosure statement:
Organization/institution whose products or services will be discussed: US Environmental Protection Agency
Novigen Sciences, Incorporated
US Department of Agriculture
I have a significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.
Relationship: I am employed by US Department of Agriculture.