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The 130th Annual Meeting of APHA |
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The 130th Annual Meeting of APHA |
M Zhu, Center for Environmental Health, Congenital Malformations Registry, Flanigan Square, Rm 200, 547 River Street, Troy, NY 12180, 518-402-7764, mxz04@health.state.ny.us
Study objectives: examine the relationship between maternal birthplace and major congenital malformations among Hispanics. Study significance: one of the few research to document Hispanic subgroups, and combine maternal and paternal birthplace. Data: New York State (NYS) Congenital Malformations Registry (CMR) and Birth Certificates (BC). Methods: Cases were live born singleton infants with major birth defects born to NYS resident Hispanic mothers reported to CMR from 1983 to 1997. Controls were randomly selected live born singleton births without major birth defects from BC. Logistic regression was used to adjust for paternal Spanish origin, maternal education, maternal age, maternal residence, prenatal care utilization, and infant’s sex. Results: For overall congenital malformations, the adjusted odds ratio (aOR) comparing US-born to foreign-born mothers was 1.13 with 95% confidence interval (CI): 1.08-1.19. Compared with US-born mothers, the aORs for mothers born in Central or Southern America, and Cuba were 0.84 and 0.74 respectively. There was no additive effect when combining maternal and paternal birthplace. US-born mothers showed positive association with cardiovascular defects (aOR 1.17, 95% CI 1.09-1.26), genitourinary defects (aOR 1.12, 95% CI 1.02-1.22), musculoskeletal defects (aOR 1.14, 95% CI 1.02-1.28), clefts (aOR 1.25, 95% CI 1.06-1.47), and tetralogy of Fallot (aOR 1.31, 95% CI 1.02-1.68). Conclusion: US-born Hispanic mothers had higher risk to deliver live born singleton infants with major congenital malformations than foreign-born Hispanic mothers. Relevance to Public Health: extensively examine the impact of maternal birthplace on major congenital malformations among Hispanic live births (1 fifth of total NYS live births).
Learning Objectives:
Presenting author's disclosure statement:
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.