The 131st Annual Meeting (November 15-19, 2003) of APHA

The 131st Annual Meeting (November 15-19, 2003) of APHA

3120.0: Monday, November 17, 2003 - 11:42 AM

Abstract #66106

Salivary gland cancer mortality in relation to occupational exposure among African American and white workers in the United States

Robin Taylor Wilson, MA, PhD, Lee E. Moore, PhD, and Mustafa Dosemeci, PhD. Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, 6120 Executive Blvd., Bethesda, MD 20892, 301-451-5034,

Background: Unlike other cancers of the head and neck, tobacco use is not associated with cancers of the salivary gland. Findings with respect to occupational exposures and viral agents are suggestive, requiring further investigation. Methods: We conducted a death certificate-based case-control study, including African American (AA) (168 cases, 672 controls) and white (2237 cases, 8748 controls) men and women identified from 24 states during 1984-89. Controls were frequency matched by 5-year age group, sex, race, and geographic region, excluding infectious causes of death. A job exposure matrix based on occupation/industry code (1980 US Census) was used to estimate exposure probability and intensity. Race and sex-stratified multiple logistic regression models estimated adjusted Odds Ratios (aOR: age, socio-economic (SES) and marital status adjustment). Results: A significantly higher proportion of AA (20.8%) cases were under age 50, compared with whites (8.8%; p<0.001). Higher SES was associated with higher mortality risk, increasing in a dose-dependent fashion among men. Occupations with moderate physical activity were associated with a 20% reduced mortality risk among men in both groups, compared with sedentary occupations (aOR=0.8; 95% CI: 0.61-0.99, white; aOR=0.8; 95% CI; 0.19-3.69, AA). Ionizing radiation, formaldehyde, solvents, ultraviolet radiation, and animal contact were significantly associated with elevated risk among white males. Results for formaldehyde, solvents, benzene, and animal contact exposures were suggestive for AA women, although not statistically significant. Industry and occupation-specific findings are also presented. Conclusion: These findings confirm previous associations with respect to higher SES and ionizing radiation and suggest new exposures for investigation.

Learning Objectives:

Keywords: Occupational Exposure, Cancer

Presenting author's disclosure statement:
Organization/institution whose products or services will be discussed: None.
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.

Chronic Disease Epidemiology

The 131st Annual Meeting (November 15-19, 2003) of APHA