The 131st Annual Meeting (November 15-19, 2003) of APHA

The 131st Annual Meeting (November 15-19, 2003) of APHA

5023.0: Wednesday, November 19, 2003 - 8:30 AM

Abstract #71614

Pesticide Exposure in Women of Reproductive Age: A U.S.-Mexico Border Study

Raquel Sabogal, MSPH, National Center for Environmental Health, Centers for Disease Control and Prevention, 1600 Clifton Rd., NE, MS E-23, Atlanta, GA 30333, 404-498-1374, and Martha E Harnly, MPH, California Dept Health Services, Environmental Health Investigations Branch, 1515 Clay, Suite 1700, Oakland, CA 94612.

To define exposures among women of reproductive age who live along the agricultural areas of the U.S.-Mexico border, 100 women were recruited from community clinics in October 2001. We selected women who had no self-reported history of infertility, were not pregnant at the time of the study, and who lived in the Imperial Valley of California, USA for at least the previous two weeks. Each woman signed a consent form, participated in a 30-45 minute lifestyle interview (English or Spanish), and provided a urine sample. Urine samples were sent to the Centers for Disease Control and Prevention (CDC) laboratory and analyzed for 34 metabolites from agricultural and residential pesticides. We compared study results with national population-based reference values. Of the 34 metabolites analyzed, the percentage of samples above the detection limit ranged from 0% (2,4,5-trichlorophenoxy acetic acid) to 100% (1-naphthol) and averaged about 40%. For the 16 metabolites with reference values, five pesticide metabolites (diethyldithiophosphate, 2-isopropoxyphenol, 2,4-dichlorophenol, 2,4,5-trichlorophenol, and carbofuranphenol) were above the 90th percentile of the national reference values. Recent exposure to organophosphates and chlorinated phenolic pesticides is indicated. Metabolites without reference values will be evaluated by comparing them with literature values. Biomonitoring results are linked to reported agricultural pesticide use and an analysis with questionnaire variables, e.g., occupation, will be presented. These results provide information about the range of pesticide exposure among women who live in an agricultural community. Such results may ultimately provide the basis for exposure reduction efforts, if warranted.

Learning Objectives:

Keywords: Environmental Exposures, Pesticides

Presenting author's disclosure statement:
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.

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The 131st Annual Meeting (November 15-19, 2003) of APHA