 | The 131st Annual Meeting (November 15-19, 2003) of APHA |
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| The 131st Annual Meeting (November 15-19, 2003) of APHA |
Neal Benowitz, MD, Division of Clinical Pharmacology and Experimental Therapeutics, University of California, San Francisco, 1001 Potero Ave, San Francisco, CA 94110, Jonathan Samet, MD, MS, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Suite W6041, Baltimore, MD 21205, Witold Zatonski, MD, PhD, Cancer Epidemiology and Prevention Department, Poland, The Maria Sklodowska-Curie Cancer Center & Institute of Oncology, 5 WK Roentgen Street, 02-781 Warsaw, Poland, +48 22 643 92 34, zatonskiw@coi.waw.pl, Mauricio Hernandez, MD, ScD, Director Ejecutivo del CISP, Instituto Nacional de Salud Pública, Av. Universidad 655, 3er. Piso, Col. Santa Maria, Cuernavaca, 62508, Mexico, and Ma Jiemin, PhD, Chinese Academy of Medical Sciences, 27 Nan Wei Road, Beijing 100050, China.
Cigarette smoking is maintained by addiction to nicotine. Intake of nicotine from cigarette smoking may vary from country to country, due to cultural and/or genetic differences, and on differences in the products smoked. Cotinine is the main proximate metabolite of nicotine. Concentrations of cotinine measured in blood, saliva or urine can be used as a marker of daily intake of nicotine from tobacco. Saliva cotinine concentrations were measured and information on smoking behavior Collected in smokers from China (N=537), Mexico (N=1246) and Poland (N=601). The average number of cigarettes smoked per day and the average saliva cotinine concentrations were 16.3 and 212 ng/ml in China; 15.2 and 193 ng/ml in Mexico, and 20.7 and 254ng/ml in Poland. The relationship between the number of cigarettes smoked per day and saliva cotinine was similar in different countries. Cotinine levels increased linearly with consumption of up to 20 cigarettes per day, then the curve flattened out. The cotinine concentration per cigarette smoked was similar among countries, suggesting that the intake of nicotine per cigarette is similar in smokers of the different countries. Overall nicotine intake, presumably reflecting smoke exposure, was greatest in Polish smokers, owing to a higher level of cigarette consumption. Information on nicotine intake from smoking may help us understand differences in smoking -related disease risks, and may help in determining optimal cessation therapies among smokers in different countries.
Learning Objectives:
Presenting author's disclosure statement:
I have a significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.
Relationship: Government employee