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[ Recorded presentation ] Recorded presentation

Incidence of prostate cancer in relation to time windows of exposure to metalworking fluids

Ilir Agalliu, MD, ScD1, Ellen A. Eisen, ScD2, David Kriebel, ScD2, Margaret M. Quinn, ScD, CIH2, and David H. Wegman, MD, MSc3. (1) Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-A402, P.O. Box 19024, Seattle, WA 98109, 206-667-7134, iagalliu@fhcrc.org, (2) Department of Work Environment, University of Massachusetts Lowell, 1University Avenue, Lowell, MA 01854, (3) Dean, School of Health and Environment, University of Massachusetts Lowell, 3 Solomont Way, Suite 1, Lowell, MA 01854-5121

To examine whether exposure to metalworking fluids (MWF) is associated with prostate cancer, we conducted a nested case-control study of 872 incident cases in a cohort of autoworkers. Our objectives were to examine exposure-response curves for MWF and prostate cancer by using semi-parametric modeling and explore time windows of exposure based on latency. Cases were identified through Michigan cancer registry from 1985 till 2000. Controls were selected using incidence-density sampling, 5:1 ratio. Using cumulative exposure (mg/m3-years) as the dose, we examined different lags and then consecutive exposure windows, for example: ³25 and <25 years before risk age. We used penalized splines to model risk as a smooth function of exposure, and controlled for race and calendar time of diagnosis. On average, cases were 70 years old when diagnosed, and 27% were black. Risk of prostate cancer was increased with exposure to soluble and straight MWF ³25 years before risk age, but not with exposure <25 years. The relationship with soluble was piecewise linear, with a small increase in risk at lower exposures followed by a steeper rise. By contrast, the relationship with straight MWF was linear with a relative risk of 1.12 per 10 mg/m3-years of exposure. Results provide evidence that exposure to MWF is associated with prostate cancer among autoworkers. They also support a latency period at least 25 years for prostate cancer development. This study also contributes to the literature of non-parametric modeling applied to occupational studies.

Learning Objectives:

Keywords: Epidemiology, Occupational Health

Presenting author's disclosure statement:
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.

[ Recorded presentation ] Recorded presentation

Dangerous Work: Occupational Epidemiology

The 132nd Annual Meeting (November 6-10, 2004) of APHA