Julie C. McLaughlin, MS, MPH¹, Aruna V. Sarma, PhD², Rodney Dunn, MS¹, Kathleen A. Cooney, MD³, James E. Montie, MD⁴, John T. Wei, MD⁵, and David Schottenfeld, MD⁶. (1) Urology, University of Michigan, 1016 Women's Trailer, 1500 E. Medical Center Dr., Ann Arbor, MI 48109, 734-663-7428, juliecm@med.umich.edu, (2) Urology, Epidemiology, University of Michigan, 1016 Women's Trailer, 1500 E. Medical Center Dr., Ann Arbor, MI 48109, (3) Internal Medicine and Veterans Health Administration, University of Michigan, 7310 CCGC, Box 0946, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, (4) Urology Surgery, University of Michigan, 2916 TC, 1500 E. Medical Center Dr., Ann Arbor, MI 48109, (5) Department of Surgery/Urology, The University of Michigan, 2916 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0330, (6) Department of Epidemiology, School of Public Health, The University of Michigan, 109 S. Observatory, Ann Arbor, MI 48109-2029

Although coronary heart disease (CHD) is the leading cause of death and morbidity in African-American adult men, relatively little is know about the association between sex steroid hormones, hormone-related factors, and CHD in this population. The objective of the current study was to examine the associations between hormones and the prevalence of self-reported myocardial infarction (MI) and CHD in a community based-sample of 431 African-American men aged 40-79. We found in multivariate analyses that age, smoking status, and SHBG were significant predictors of MI, adjusted for hypertension, diabetes, and testosterone levels. For every S.D. increased in SHBG, the odds of MI increased 1.55 (1.09, 2.20) fold. When modeling CHD as the outcome, age, smoking status, androstenediol glucuronide (AG), estradiol, and testosterone were significant predictors of CHD, adjusted for hypertension, diabetes, education, and SHBG levels. For every S.D. increase in AG, estradiol and testosterone, the odds of CHD increased 1.46 (1.08, 1.96), 1.43 (1.02, 2.02), and 0.57 0.33, 0.98) fold, respectively. Our results suggest the hormones SHBG and testosterone are associated with MI, while androstenediol glucuronide, estradiol, testosterone, and SHBG are associated with CHD among African-American men, and warrants further investigation of these relationships in future longitudinal studies.

Learning Objectives:

• At the conclusion of the session, the participant (learner) in this session will be able to describe how sex steroid hormones and hormone related factors may be related to the development of coronary heart disease in african-amercian men

Presenting author's disclosure statement:
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.