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Julie C. McLaughlin, MS, MPH1, Aruna V. Sarma, PhD2, Rodney Dunn, MS1, Kathleen A. Cooney, MD3, James E. Montie, MD4, John T. Wei, MD5, and David Schottenfeld, MD6. (1) Urology, University of Michigan, 1016 Women's Trailer, 1500 E. Medical Center Dr., Ann Arbor, MI 48109, 734-663-7428, juliecm@med.umich.edu, (2) Urology, Epidemiology, University of Michigan, 1016 Women's Trailer, 1500 E. Medical Center Dr., Ann Arbor, MI 48109, (3) Internal Medicine and Veterans Health Administration, University of Michigan, 7310 CCGC, Box 0946, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, (4) Urology Surgery, University of Michigan, 2916 TC, 1500 E. Medical Center Dr., Ann Arbor, MI 48109, (5) Department of Surgery/Urology, The University of Michigan, 2916 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0330, (6) Department of Epidemiology, School of Public Health, The University of Michigan, 109 S. Observatory, Ann Arbor, MI 48109-2029
Introduction: The prevalence of diabetes in the U.S. is approximately 1.5 times greater among black males than white. In order to investigate this disparity, we evaluated the associations between behavioral risk factors, hormones, and diabetes in a cross-sectional analysis of a population-based sample of African-American men aged 40-79. Methods: A probability sample undertaken by the Flint Men’s Health Study in 1996 identified 817 eligible African-American men residing in Genesee County, Michigan. Subjects completed a detailed in-home epidemiologic interview, including information on potential personal and environmental risk factors for diabetes. A subgroup of 431 men provided a blood sample for analysis of 11 serum hormone/protein factors. Multivariate logistic regression models were used to assess the association of variables with prevalence of self-reported diabetes. Results: We found the overall prevalence of self-reported DM was 206.8 per 1000 men. In multivariate analyses, age, hypertension, alcohol status, BMI, smoking status, and history of heart attack were significant predictors of self-reported diabetes. In a sub-sample of 431 men evaluated for hormones, age, BMI, hypertension, smoking status, marital status, alcohol status, history of heart attack, DHEAS, estradiol, and IGF-1were significant predictors of self-reported diabetes. Conclusion: Our results suggest obesity, hypertension, and estradiol are associated with increased risk of diabetes in African-American men, and warrants further investigation of these relationships in future longitudinal studies.
Learning Objectives: At the conclusion of the session, the participant (learner) in this session will be able to
Presenting author's disclosure statement:
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.