Recorded presentation

Farnaz Vahidnia, MD, MPH¹, Brenda Eskenazi, PhD², and Nick Jewell, PhD². (1) School of Public Health, University of California at Berkeley, 140 Warren Hall, Berkeley, CA 94720-7360, 510-643-4284, fvahid@uclink.berkelely.edu, (2) Center for Children's Environmental Health Research, University of California, Berkeley, 2150 Shattuck Ave, Suite 600, Berkeley, CA 94720-7380

The authors evaluated the effect of maternal cigarette smoking and alcohol drinking as a possible risk factor for febrile convulsion in a large cohort of pregnant women. Participants included 11,826 women enrolled in the Child Health and Development Studies in California between 1959 and 1966. Women were divided into non-smokers (n= 7,587) and smokers (n= 4,239). Unadjusted odds ratio (OR) for smoking showed increased risk of febrile convulsion (OR= 1.20, 95% CI = 0.93, 1.55) that did not vary across levels of cigarette smoking (p-value for the trend = 0.99). Cox proportional hazard model, which assumed changes in hazard function with time, indicated that children of smokers are at a greater risk of febrile convulsion than those of non-smokers during the first 800 days of life, after adjusting for maternal alcohol drinking, husband smoking during pregnancy, infant’s sex, birth weight, severe congenital anomaly, and history of diarrhea and otitis media (OR = 1.37, 95% CI = 1.01, 1.87). The results also showed 2.1 times greater hazard associated with maternal smoking among children of those who are heavy drinkers (95% CI = 1.31, 3.26) during the first 800 days.

Learning Objectives: At the end of the session, the participitant will be able to

• Define Cox Proportional Hazard Model
• Describe the risk factors associated with children's febrile convulsion
• Recognize the association between maternal smoking and/or drinking and febriel convulsion

Keywords: Pregnancy, Smoking

Presenting author's disclosure statement:
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.

Recorded presentation