Back to Annual Meeting Page		American Public Health Association 133rd Annual Meeting & Exposition December 10-14, 2005 Philadelphia, PA

Abstract #110119

Ruth H. Allen, PhD, MPH¹, Anuradha Kodali, MBBS, MPH², Dana B. Barr, PhD³, Larry L. Needham, PhD⁴, and David T. Mage, PhD². (1) Health Effects Division, Office of Pesticide Programs, Environmental Protection Agency, 2039 Durand St, Reston, VA 22091, 703-305-7191, allen.ruth@epa.gov, (2) Institute for Survey Research, Temple University, 9451 Lee Highway, Apt. 1013, Fairfax, VA 22031, (3) Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Centers for Disease Control, Atlanta, GA 30341, (4) Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop F17, Atlanta, USA, GA 30341

An objection to reporting urinary pesticide concentration data with a creatinine correction for diuresis as ug analyte/ mg creatinine is that children have a much lower creatinine excretion rate than an adult because of their still developing musculature. For equal urine concentrations in ug analyte/ liter, this would make the child's standardized ratio much higher relative to the adult's. We therefore propose that such ug analyte/ mg creatinine data be multiplied by the subject's estimated creatinine production (mg creatinine/ kg body mass-day). The resulting quantity, ug analyte/ kg body mass-day, is in the units of the U.S. EPA's RfD for oral ingestions of pesticide compounds and can be compared to it as an indication of a potential health effect. We review the process of creatinine correction and the various equations found in the medical literature for infant – child – adolescent daily creatinine clearances that were developed for the purpose of adjusting pharmaceutical dosages. These pediatric creatinine clearances are compared to those we have developed in a similar manner for adults. We compare their asymptotes at age 18 to adjust for their inconsistency where both should predict the same values. We propose a new set of equations for adults and children that allow a consistent method of reporting all urinary concentration as ug pesticide /kg body mass-day without any discontinuity between them. These equations provide estimates that can be compared on the same basis that has a direct relationship to a health effect (the RfD) for the parent pesticide being studied.

Learning Objectives: Learning Objective

• Participants will be able to understand the pros and cons of creatinine correct in adults vs. children.
• Participants will better understand reference dose in various units and its implications.
• Participants will be able to better understand the role of human pesticide biomonitoring in the regulatory process.
• Participants will be able better understand the how variations in age from birth to 18 years impacts creatinine correction for children.
• Participants will be better able to understand the transition from 18 years of age to adulthood for creatinine correction in human biomonitoring data.

Keywords: Environmental Exposures, Child Health

Related Web page: www.epa.gov

Presenting author's disclosure statement:

I wish to disclose that I have NO financial interests or other relationship with the manufactures of commercial products, suppliers of commercial services or commercial supporters.