Back to Annual Meeting Page		American Public Health Association 133rd Annual Meeting & Exposition December 10-14, 2005 Philadelphia, PA

Abstract #117181

Suzaynn F. Schick, PhD, Center for Tobacco Control Research and Education, University of California, San Francisco, 530 Parnassus, Ste 366, San Francisco, CA 94143-1390, 415-502-4882, zaynn@itsa.ucsf.edu and Stanton A. Glantz, PhD, University of California, San Francisco, Center for Tobacco Control Research & Education, 530 Parnassus Ave., Suite 366, San Francisco, CA 94143-1390.

Objectives: To analyze the secondhand cigarette smoke inhalation experiments published in the open scientific literature by the tobacco industry, in the context of unpublished data from the tobacco documents.

Methods: Searches of the tobacco documents and the open scientific literature.

Results: Beginning in 1981, the tobacco industry performed experiments on the in vivo toxicology of sidestream cigarette smoke. The majority of these experiments examined sidestream smoke that was less than a minute old. However, secondhand smoke normally includes sidestream smoke that has been in the air for longer times. Chemical analyses by the industry indicated that while gas-phase components, like carbon monoxide, remain constant over time, there is a time-dependent loss of sidestream particulate matter due to deposition and adsorbtion. Ames tests showed that when fresh and aged sidestream smoke are compared on the basis of carbon monoxide content, fresh smoke is more mutagenic. When compared on the basis grams of total particulate material, fresh and aged sidestream smoke are equally mutagenic. Inhalation studies comparing fresh and aged sidestream smoke on the basis of the constant gas phase components, showed that fresh smoke was more toxic. The industry did not publish the Ames test findings showing that the per gram mutagenicity of sidestream TPM does not decrease over time.

Conclusions: The per gram mutagenicity of sidestream TPM does not change with time.

Learning Objectives:

• Understand the content and policy goals of published tobacco industry in vivo studies of secondhand smoke.
• Learn about the unpublished internal studies of secondhand smoke by the tobacco industry.
• Understand how the chemistry of secondhand smoke changes over time and how it pollutes surfaces in buildings.

Keywords: Tobacco Industry, Indoor Environment

Presenting author's disclosure statement:

I wish to disclose that I have NO financial interests or other relationship with the manufactures of commercial products, suppliers of commercial services or commercial supporters.