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APHA Scientific Session and Event Listing

Aruna V. Sarma, PhD¹, Lauren P. Wallner, MPH¹, Rodney L. Dunn, MS², James E. Montie, MD¹, and John T. Wei, MD, MS¹. (1) Department of Urology, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, 734-763-7514, asarma@umich.edu, (2) Cancer Center, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109

Introduction: Metabolic syndrome and benign prostatic hyperplasia (BPH) are significant causes of morbidity among U.S men. Literature suggests that components of metabolic syndrome are individually associated with BPH risk; however, these studies are limited to white men. The objective of this study was to examine the association between the components of metabolic syndrome and a comprehensive set of measures of BPH in a population-based sample of African-American men aged 40-79. Methods: In 1996, a probability sample of 369 African American men residing in Genesee County, Michigan without a prior history of prostate cancer/surgery completed a detailed in-home epidemiologic interview eliciting information on potential risk factors for prostate disease and medical history. Participants also underwent a comprehensive urological examination including completion of the American Urological Association Symptom Index (AUASI), serum PSA measurement, uroflowmetry, digital rectal exam, and transrectal ultrasound. Results: 24% men in this study were categorized as having at least 2 components of metabolic syndrome and 6.3% displayed all three. Abdominal obesity, history of physician diagnosed diabetes and current high blood pressure were positively associated with increased prostate volume and LUTS severity after adjustment for age. Having 2 or all of these components were positively associated with increased prostate volume. Conclusion: Our results suggest a potential role of metabolic syndrome on anatomical and symptomatic manifestations of BPH in African-American men. An increase in odds of enlarged prostate and moderate to severe symptom severity with abdominal obesity, high blood pressure and diabetes suggest increased sympathetic nerve activity in men with BPH.

Learning Objectives: At the conclusion of this session, the participant in this session will be able to

• Describe the association between the components of metabolic syndrome and the clinical symptoms of BPH in African-American men.
• Recognize the potential role of hyperinsulinemia, diabetes mellitus and abdominal obesity on the symptomatic manifestations of BPH.
• Develop further strategies to determine possible mechanisms, prevention strategies, and treatment outcomes among men with features of the metabolic syndrome and BPH.

Keywords: Diabetes, African American

Presenting author's disclosure statement:

Not Answered