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Preet K. Dhillon, MPH, PhD, Bombay Cancer Registry, Indian Cancer Society & IARC Research Training Fellowship, 3450 Cody Road, Sherman Oaks, CA 91403-5010, 818.905.9526, preet@u.washington.edu, Freddie Bray, BSc, MSc, PhD, The Cancer Registry of Norway, Montebello, N-0310 Oslo, Norway, and B.B. Yeole, MSc, PhD, Bombay Cancer Registry, Indian Cancer Society, 74 Jerbai Wadia Road, Parel, Mumbai, 400 012, India.

We conducted an age-period-cohort (APC) analysis on the incidence trends of lymphoma and leukemia in persons aged 30-64 years living in Mumbai, India between 1976 and 2000. The analysis focuses on period and cohort-specific interpretations of the observed trends, with an emphasis on younger generations diagnosed in the recent past. The Bombay Cancer Registry was used to identify new lymphoma and leukemia diagnoses in this urban Indian population.

In males, the age-adjusted lymphoma rate (based on the WHO world standard) increased from 21.7 to 29.9 per 100,000 (1.5% annual change - PAC) while the leukemia rate increased from 19.2 to 23.3 per 100,000 (0.9 PAC). In females, the lymphoma rate increased from 12.0 to 21.3 per 100,000 (3.1 PAC) and the leukemia rate changed from 12.0 to 18.8 per 100,000 (2.3 PAC) for the same 25-year period. In males, the APC graphs do not reveal a consistent birth cohort or period effect for either lymphoma or leukemia rates. In females, there is an increasing trend of lymphoma incidence for more recent birth cohorts and for diagnoses in later periods of time. The leukemia data in females however, is less consistent.

This is part of a time-trends analysis series of cancer incidence based on cases identified by the Bombay Cancer Registry, which was established in 1964 and has regularly reported high quality data for international case registration and comparative studies for nearly three decades. The only pattern emerging from these data is seen in women, in whom there is an overall rise in lymphoma incidence over time.

Learning Objectives:

• Describe the overall trend of lymphoma and leukemia incidence in Mumbai residents from 1976-2000.
• Assess the relative contribution of age, period and cohort effects, if present.
• Evaluate whether individual forms of disease, NHL vs. Hodgkin's disease follow same overall pattern.

Keywords: Cancer, India

Presenting author's disclosure statement:

Not Answered