159267 Reducing the risk of recurring preterm birth: The North Carolina 17P Project

Wednesday, November 7, 2007: 3:25 PM

Sarah Verbiest, MPH, MSW, DrPH , Center for Maternal and Infant Health, University of North Carolina at Chapel Hill, Chapel Hill, NC
Joe Holliday, MD, MPH , Women's Health Branch, North Carolina Division of Public Health, Raleigh, NC
Kathryn Menard, MD, MPH , Division of Maternal Fetal Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC
Preterm birth is responsible for over 70% of perinatal morbidity and mortality with one out of eight infants in the United States born before 37 weeks gestation. Recent research has found one way to reduce the risk of recurring preterm birth by 33% in a specific population of women by giving weekly injections of a drug (17P) to pregnant women who have had a previous early birth. North Carolina launched a project to move this new research into practice statewide, with a focus on low-income and minority women. There are many significant barriers to achieving full access to 17P. In June 2006 the North Carolina General Assembly appropriated funds to begin to address these challenges. The appropriation made 17P available free of charge to pregnant women who met the clinical criteria and were Medicaid recipients. It provided funds to expand education about the drug to consumers, providers and public health partners. The legislation required that the project be led by an advisory group with representatives from across North Carolina, that research be done with other states to learn more about their use of 17P, and that an evaluation be conducted of the project to understand more about the barriers and facilitators faced by women and providers. The presentation will share information about the success and challenges faced by the 17P project as well as the results of the evaluation and study. This topic is very current and the approach taken to speed translation research is innovative.

Learning Objectives:
1.Describe the role of 17 alpha hydroxyprogesterone (17P) in reducing recurring preterm birth. 2. Identify the barriers and facilitators to increasing access to 17P from the perspective of consumers, health care providers, payers, and public health. 3. Describe North Carolina’s innovative program to increase access to 17P for minority and low income mothers. 4. Discuss the ethical and policy challenges inherent in translational research.

Keywords: Access to Care, Prenatal Interventions

Presenting author's disclosure statement:
Organization/institution whose products or services will be discussed: FDA approval for the use of 17P for preterm birth prevention is pending. ACOG issued a position paper in 2003 encouraging the use of 17P. About 60% of maternal fetal specialists use 17P.

Any relevant financial relationships? No
Any institutionally-contracted trials related to this submission?

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.