160182 Association between maternal nutrition status and Atopy in infants at three years of age

Wednesday, November 7, 2007

Bohyun Park , Preventive Medicine, College of Medicine, Ewha Womans University, Seoul, South Korea
Hyesook Park , Preventive Medicine, Ewha Womans University, seoul, South Korea
EunAe Park , Pediatrics, Ewha Womans University, seoul, South Korea
Youngju Kim , Obstetrics and Gynecology, Ewha Womans University, seoul, South Korea
JungWon Min , Preventive Medicine, Ewha Womans University, seoul, South Korea
Kyoungae Kong , Preventive Medicine, Ewha Womans University, seoul, South Korea
Juhee Hong , Preventive Medicine, Ewha Womans University, Seoul, South Korea
Oh SeYoung , Department of Food and nutrition, Kyunghee university, Seoul, South Korea
Aims: Prevalence of atopy has been increasing during the last decades. Antioxidant status might be related to the sensibility of atopic disease in childhood. We hypothesized that maternal nutrition and oxidative stress would affect the development of atopy in infants at 3 years of age.

Material and Methodology: From the ongoing birth cohort at Ewha Womans University Hospital, we compared the postnatal atopic history and maternal antioxidant concentrations(retinol, vitamin C, tocopherol, folate) during the 25-28 weeks of gestation of their pregnancy (N=154).

Results: Maternal folate and vitamin C concentration was related to a lower risk of atopy in the infants. There was a dose-response relation between maternal nutrition and infant's atopy. The means of maternal folate were significantly lower in infants who had atopic disease compared with the nonatopic infants [2.31ng/ml (95%CI -2.52-7.15) vs 7.29 ng/ml (95%CI 5.95-8.63), p<0.05]. The average maternal vitamin C was higher for those with nonatopic subjects (p=0.06).

Conclusion: The results suggest that the maternal vitamin C and folate metabolism may be causally related to the development of atopy. “This research was supported by Korea Science and Engineering foundation Fund (R01-2006-000-10887-0).”

Learning Objectives:
To assess the effects of maternal nutrition and oxidative stress would affect the development of atopy in infants at 3 years of age.

Presenting author's disclosure statement:

Any relevant financial relationships? No
Any institutionally-contracted trials related to this submission?

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.

See more of: Maternal Child Health - Data and Epidemiology
See more of: Maternal and Child Health