160551 Factors associated with diabetes and impaired fasting glucose in individuals with a family history

Tuesday, November 6, 2007: 9:20 AM

Christina M. Lefante, MPH , Department of Epidemiology, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA
L. Joseph Su, PhD, MPH , Department of Epidemiology, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA
Eric Ravussin, PhD , Pennington Biomedical Research Center, Baton Rouge, LA
S. Michal Jazwinski, PhD , Department of Biochemistry & Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, LA
Katie E. Cherry, PhD , Department of Psychology, Lousiana State University, Baton Rouge, LA
David A. Welsh, MD , Department of Pulmonary & Critical Care Medicine, Lousiana State University Health Sciences Center, New Orleans, LA
Jennifer C. Rood, PhD, DABCC, FACB , Pennington Biomedical Research Center, Baton Rouge, LA
Crystal Traylor, WHNP , Pennington Biomedical Research Center, Baton Rouge, LA
     
According to the NHANES (1999-2000) survey, an estimated 16.7 million U.S. adults aged 20 years or greater had diabetes while an estimated 12.3 million had impaired fasting glucose (IFG)1, a potential indicator of progression to type 2 diabetes2. The large number of U.S. adults with and predisposed to diabetes demonstrates the need for earlier detection. This study assessed characteristics of undiagnosed diabetes and pre-diabetes in the Louisiana Healthy Aging Study, a multidisciplinary population-based study that examines the determinants of healthy aging. Overall, 619 individuals aged 20 to 102 were randomly sampled and recruited using Medicare Beneficiary Enrollment and Louisiana Voters registration files. Self-reported diabetes and family history of a first degree relative with diabetes was ascertained. Fasting blood glucose was measured and participants were characterized pre-diabetic or diabetic based on American Diabetes Association guidelines. Chi-square and logistic regression were used to assess the association between fasting glucose concentration and family history by self-reported diabetes status. Among individuals not reporting a diagnosis of diabetes, 8%(n=15) with a family history had diabetes while 39.6%(n=74) had pre-diabetes. Family History (OR:1.49 CI:1.05-2.09), body mass index (OR:2.08 CI:1.45-2.97), male gender (OR:2.37 CI:1.69-3.33), and age >65 (OR:2.03 CI:1.44-2.88) were strong predictors of having diabetes or IFG after adjusting for confounding factors. These findings suggest that a significant proportion of individuals in this study at risk for diabetes are not receiving proper screening. This research was supported by the Louisiana Board of Regents Millennium Trust Health Excellence Fund [HEF(2001-06)-02] and National Institute on Aging [P01AG022064].

Learning Objectives:
1. Identify individuals at risk for impaired fasting glucose and diabetes. 2. Recognize the need for diabetes screening

Keywords: Diabetes, Risk Factors

Presenting author's disclosure statement:

Any relevant financial relationships? No
Any institutionally-contracted trials related to this submission?

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.

See more of: Diabetes Epidemiology
See more of: Epidemiology