170048 Relationship between serum levels of heavy metals and Parkinson's disease in China

Sunday, October 26, 2008

Tetsuhito Fukushima , Department of Hygiene and Preventive Medicine, Fukushima Medical University, Fukushima City, Japan
Manganese poisoning is well known to result in Parkinsonian symptoms. The present study examined the relation between serum levels of heavy metals and Parkinson's disease in China. Subjects comprised 37 Parkinson's disease patients (22 men, 15 women; mean (±SD) age, 63.3 ±10.9 years) who had been patients for <3 years, and sex- and age-matched controls with no Parkinson's disease, but with headache, dizziness etc. attending the outpatient clinic of Xiangfan No. 1 People's Hospital in Hubei, China. Intake of metals was computed from a nutritional survey by ingestion frequency per week before diagnosis of Parkinson's disease. Morning blood samples were collected before breakfast. Serum was used to measure concentrations of manganese, iron, copper and zinc. Informed consent was obtained from all subjects, and the study protocol was approved by the ethics committee of Fukushima Medical University. Fasting serum levels of manganese, iron, copper and zinc in Parkinson's disease patients were 0.028±0.034 microgram/ml, 1.55±0.97 microgram/ml, 1.03±0.26 microgram/ml and 0.76±0.27 microgram/ml, respectively. Levels in controls were 0.012±0.005 microgram/ml, 0.99±0.68 microgram/ml, 0.99±0.26 microgram/ml and 0.70±0.24 microgram/ml, respectively. Serum manganese and iron levels were significantly higher in Parkinson's disease patients than in controls. No differences were seen in intake of each metal between groups, but water and tea intakes were significantly lower in Parkinson's disease patients. In China, accumulation of manganese and iron in blood might be involved in the etiology of Parkinson's disease.

Learning Objectives:
1. Show serum concentrations of manganese, iron, copper and zinc in Parkinson’s disease patients in China, and the influence of their intake from food. 2. Discuss the effect of heavy metals in food and drinking water on pathogenesis of Parkinson’s disease. 3. Recognize it is not necessary to be cautious of usual intake of manganese and iron from food or drinking water, but increase of the serum level.

Keywords: Epidemiology, Nutrition

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I have had no financial interest with any commercial entity.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.