171589 Association between Maternal Alcohol USE in Early Pregnancy and Congenital Heart Defects

Tuesday, October 28, 2008: 10:50 AM

Walter A. Mateja, MPH, MPA , College of Health Professions, Department of Public Health, Temple Unversity, Philadelphia, PA
This study will employ a case-control design to examine the odds of congenital heart defects among infants born to women who report alcohol consumption, frequent drinking and binge drinking in the three months prior to pregnancy. Alcohol use and other risk factors prior to pregnancy will be obtained from the Pregnancy Risk Assessment Monitoring Surveillance (PRAMS), an ongoing national study administered in selected participating states. Birth defects data will be derived from linked birth certificates from 10 participating states over a ten year period (1996-2005). The PRAMS data are representative of births occurring annually in each state and contain responses from post-partum mothers that can be linked with birth certificate data.

For this assessment, cases will include infants born with a congenital cardiac defect as indicated on the birth certificate. There will be two control groups. One control group will consist of infants with no indication of a congenital abnormality on their birth certificate. A second control group will include infants born with Down's syndrome indicated on their birth certificate in order to investigate potential reporting and recall biases. Unadjusted odds ratios for alcohol use, frequent drinking, binge drinking, demographic, behavioral, and health related variables will be computed. Significant factors will be entered into a multinomial logistic regression analysis for model fitting and calculation of adjusted odds ratios predicting the role of pre-pregnancy alcohol use on congenital cardiac defects.

Alcohol-use is an identifiable and preventable risk factor among women seeking to become pregnant. Maternal alcohol-use during pregnancy may be related to congenital cardiac defects, one of the leading types of birth defects. This study seeks to assess the strength of this relationship.

Learning Objectives:
1. Assess the association of maternal alcohol use and the odds of congenital heart defects among offspring. 2. Discuss the role of reporting and recall biases in retrospective case-control studies of birth defects.

Keywords: Alcohol Use, Birth Defects

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: this abstract is my dissertation study.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.