171801 Non-Hodgkin's Lymphoma Incidence: A Comparison of Demographic Patterns and Temporal Trends Between Pennsylvania and SEER Registries

Wednesday, October 29, 2008: 12:50 PM

Yueh Ying Han , Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA
Joel L. Weissfeld , Graduate School of Public Health: Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA
Devra Lee Davis , Center for Environmental Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA
Objective: Previous analyses of Surveillance Epidemiology and End Results (SEER) data have documented striking time-related increases in non-Hodgkin's lymphoma (NHL) incidence in the United States. Using data from the Pennsylvania Cancer Registry (PCR), which is not part of SEER, this study evaluated whether patterns of NHL differ in these two areas. Methods: Joinpoint and age-period-cohort (APC) regression models were applied to summarize gender- and race-specific NHL incidence time trends in Pennsylvania and the SEER registries between 1985 and 2004. Multiple regression analysis was used to identify demographic factors associated with age-adjusted county-specific NHL patterns in Pennsylvania. Results: According to APC analyses, Pennsylvania NHL incidence increased, on average, 1.5% and 2.5% annually in white and black men and 1.6% and 3.2% annually in white and black women. Average annual increase of gender- and race- specific NHL incidence in the SEER registries was similar to the PCR, except for white men (0.3% per year). Diffuse lymphoma appeared to be the most important contributor to the increase of NHL incidence in PCR and SEER registries. In Pennsylvania, NHL incidence was higher in counties with a greater percentage of urban residents (p=0.005). Conclusion: Though not identical, NHL incidence patterns in Pennsylvania and the SEER registries were generally parallel. The ecologic association observed in Pennsylvania NHL incidence and urban residence may be relevant to NHL patterns in the entire United States. Future work should explore what aspects of urbanization may account for the association with increased NHL risk.

Learning Objectives:
1.Identify and compare temporal changes in NHL incidence between Pennsylvania and SEER registry. 2.Understand the need for research investigating controllable factors that may account for these patterns.

Keywords: Cancer, Risk Factors

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am the PI of the study
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.

See more of: Cancer Epidemiology II
See more of: Epidemiology