180841 Exposure to persistent organic pollutants further increases risk of myocardial infarction in hypertensive populations

Tuesday, October 28, 2008: 12:50 PM

Alexander V. Sergeev, MD, PhD, MPH , School of Health Sciences, College of Health and Human Services, Ohio University, Athens, OH
David O. Carpenter, MD , Institute for Health and the Environment, University at Albany, SUNY, Rensselaer, NY
Purpose: Environmental exposure to persistent organic pollutants (POP) is an emerging risk factor for atherosclerosis-related cardiovascular diseases, including myocardial infarction (MI). Some studies also suggest that POP exposure increases the risk of hypertension, a well-established MI risk factor. A study of environmental exposure to POP and MI in hypertensive populations would clarify whether this exposure increases MI risk per se or if this effect is hypertension-dependent. Hypothesis: MI hospitalization rates would be higher in POP-exposed hypertensive populations than in unexposed hypertensive populations. Methods: We conducted an ecologic study of MI in POP-exposed and unexposed hypertensive populations. To examine the effect of POP exposure on MI hospitalization rates, we used the New York Statewide Planning and Research Cooperative System data on 92,772 hospital discharges for MI in 25-74 year-old hypertensive patients for a 12-year period (1993-2004). Residents of zip codes containing or abutting POP-contaminated sites were considered environmentally exposed. Relative risks were estimated by Poisson regression, adjusting for potential confounders. Results: MI hospitalization risk was 20.2% higher for POP-exposed hypertensive females compared to unexposed females (p<0.05); for males, a 5.8% increase was observed (p>0.05). Also, MI hospitalization risks were 64.8% higher for African Americans (p<0.05) and older age groups (compared to 25-34 year-olds, p<0.05); these findings, consistent with current knowledge of MI, prove the quality of our model. Conclusions: Environmental exposure to POP, per se, increases the risk of MI in hypertensive populations. Atherogenic effect of POP can be gender-modified due to gender differences in POP metabolism.

Learning Objectives:
1. Describe the concept of involuntary environmental exposure to persistent organic pollutants (POP). 2. Discuss epidemiological measures of environmental exposure to POP. 3. List emerging cardiovascular health hazards associated with exposure to POP.

Keywords: Environmental Health Hazards, Emerging Health Issues

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I have made substantial contribution to the research and to abstract preparation: designed the research, performed statistical analysis of the data, interpreted the results, drafted and revised the manuscript (abstract).
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.