187001 Survival predictors in Connecticut women with ovarian cancer, 1985-2004: A population-based study

Wednesday, October 29, 2008: 1:20 PM

Angela M. Cierzniewski, MPH Candidate , Dept. of Public Health, Indiana University School of Medicine, Indianapolis, IN
Indiana M. Strombom, PhD , Indiana University School of Medicine, Adjunct Assistant Professor of Public Health, Indianapolis, IN
In 2006 alone, the American Cancer Society estimated that there were over 20,000 new cases diagnosed and over 15,000 deaths from ovarian cancer. While there are many risk factors for developing ovarian cancer, what predicts a woman's survival after she is diagnosed? Age and stage of diagnosis are known survival predictors. The association between race and ovarian cancer survival is not as well established.

Predictors of survival among women (aged 40 and older) diagnosed with staged ovarian cancer from 1985 to 2004 (aggregated and analyzed in two 10-year time periods) in the Connecticut Surveillance Epidemiology and End Results (SEER) database were retrospectively analyzed using logistic regression. While stage of cancer, race, and age at diagnosis predict survival, urbanity of a woman's residential county does not. From 1985-1994, compared with distant stage, women with localized cancer are more likely to survive to 12, 24, 36, and 60 months post diagnosis [varied from (OR= 16.02, CI: 9.25-27.74) to (OR= 17.89, CI: 12.15-26.34)]. Similar results were seen in the 1995-2004 data, as well as with regional tumors. Age at diagnosis was also significant [varied from (OR=0.93, CI: 0.92-0.94) to (OR=0.95, CI: 0.94-0.96)]. The younger the woman was when diagnosed, the better her chance of survival. Race predicted survival only in the 1995-2004 data. At 12, 24, 36, and 60 months post diagnosis, black women compared to white women had a lower chance of survival, after controlling for age and stage of diagnosis [varied from (OR=0.34; CI: 0.14-0.87) to (OR=0.49, CI: 0.26-0.92)].

Learning Objectives:
1. Access the frequency of ovarian cancer in Connecticut by age, stage, and race 2. Describe the association seen between ovarian cancer survival and race in Connecticut women 3. Recognize the necessity of early detection of ovarian cancer in women of all races

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: Currently enrolled in second year of MPH program at Indiana University. In addition, I analyzed all of the data that was collected for this project and wrote the report.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.

See more of: Cancer Epidemiology II
See more of: Epidemiology