190211 Hospital-based case-control study of the association between body mass index and endometrial cancer in Puerto Rican women

Sunday, October 26, 2008

Eileen Y. Charneco, MS , Graduate School of Public Health, University of Puerto Rico, Medical Sciences Campus, San Juan, PR
Ana P. Ortiz, PhD , Graduate School of Public Health, University of Puerto Rico, Medical Sciences Campus, San Juan, PR
Heidi Venegas, MS , Graduate School of Public Health, University of Puerto Rico, Medical Sciences Campus, San Juan, PR
Josefina Romaguera, MD, MPH , School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, PR
Sharee Umpierre, MD , School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, PR
Obesity is an established risk factor for endometrial cancer. However, this association has not been studied in Puerto Rico, where overweight (33%) and obesity (27%) have achieved epidemic levels. A hospital based case-control study was designed to evaluate the association between body mass index (BMI) and endometrial cancer. Seventy-four prevalent endometrial cancer cases diagnosed from January 2004-August 2007 and a random sample of 88 healthy controls were recruited from the Medical Center of San Juan, Puerto Rico. Demographic, lifestyle, anthropometric and clinical information was obtained via structured telephone interviews and medical record review. Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CI). Mean age at diagnosis for cases was 56.3 12.1 years. Cases were most likely than controls to be diabetic, hypertensive and less likely to be physically active; yet, none of the reproductive characteristics were associated with endometrial cancer. Increasing BMI was associated with increased odds of endometrial cancer in bivariate analysis (p- for trend <0.0001). Women with a BMI ≥ 30 kg/m2 had 4-fold greater possibility of endometrial cancer (OR=4.1; 95% CI: 1.8-8.6) than non-obese women (BMI< 30 kg/m2), after adjusting for age, education, employment status, hypertension diagnosis, use of oral contraceptives and consumption of turkey/chicken. Consistent with previous studies world-wide, adult obesity was a strong predictor for endometrial cancer in this sample of Puerto Rican women. Primary prevention programs to avoid obesity and promote healthy life styles are warranted to reduce endometrial cancer risk in this population.

Learning Objectives:
1. Describe factors associated to endometrial cancer in Puerto Rico 2. Evaluate the association between BMI and endometrial cancer in a clinic-based case-control study of Puerto Rican women

Keywords: Cancer, Obesity

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: This presentation is based on my MS Epidemiology thesis research.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.