190798 Psychosocial Predictors of Depressive Symptomatology among Young Adults with HPV Infection

Tuesday, October 28, 2008: 12:50 PM

Jamie L. Fairclough, MPH, PhD , Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC
Stress and depression are two psychosocial factors associated with decreased immune functioning in persons with Human Papillomavirus (HPV) infections. A number of studies have concluded that persons with STIs experience higher levels of stress and depression. This study tested a general health stress (GHS) model and a gynecologic/urologic health stress model's ability to predict depressive symptomatology among young adults with HPV, other STIs, and no STIs. The mediating/moderating effects of partner connectedness and self-esteem on these relationships were also examined. The study sample consisted of 322 Add Health Wave III participants. A series of hierarchical regression analyses were conducted for predictive modeling and a post hoc 3x2 factorial ANCOVA was used to examine main and interaction effects of infection and gender on depressive symptomatology. Among respondents with HPV, gender (being female) was a significant predictor of depressive symptomatology. The GHS predictive model explained 19.4% and 12.0% of the variance in depressive symptomatology among the HPV and STI groups, respectively. For respondents with no STIs, self-esteem was the only significant predictor of depressive symptomatology. The gynecologic/urologic health stress model did not predict depressive symptomatology in any group. Results also indicated no significant main effects of infection and gender, nor were there significant interaction effects when variation attributed to self-esteem was partitioned through covariance; however, self-esteem was found to significantly adjust for depressive symptomatology scores. In conclusion, general health stress, partner connectedness, and self-esteem play an important role in the psychological functioning of young adults with HPV and other STIs.

Learning Objectives:
1. Identify factors that contribute to depressive symptomatology among young adults with HPV infection 2. Apply predictive modeling techniques to depression, health stress, and HPV research 3. Describe main and interaction effects of HPV/STI infection and gender on depressive symptomatology

Keywords: STD, Adult and Child Mental Health

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I have been formally trained in public health research methods and was the primary investigator of this study.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.