Relation of the Tuesday, November 10, 2009: 1:35 PM Takuji Kishimoto, MD, PhD , Environmental and Preventive Medicine, Tottori University, Yonago, Japan Yoneatsu Osaki, MD, PhD , Environmental and Preventive Medicine, Tottori University, Yonago, Japan Aya Tahara, MD , Environmental and Preventive Medicine, Tottori University, Yonago, Japan Objective: To assess the relationship between b2 - adrenergic receptor (ADRB2) Arg16Gly polymorphism and metabolic syndrome (MS) in Japanese workers. Method: In a retrospective cohort study, the participants of regular health examination in 1998 – 2006 on the Shimane Prefecture of Japan were examined the relationship between ADRB2 Arg16Gly polymorphism and MS. Covariates included sex, age, food balance, smoke, alcohol, exercise and sleeping - status. We constructed proportional hazards models of MS. Results: A total of 865 participants were followed up for an average of 7.41 years. The allele frequencies of the 16Arg and 16Gly were 0.47 and 0.53, respectively. After multivariable adjustment, the hazard ratio of MS was 1.79 (95% confidence interval 1.06 – 3.00, p<0.03) among carriers of the 16Gly allele versus non – carriers. Conclusion: The ADRB2-16Gly allele may increase the risk of MS in this population. Learning Objectives: We evaluated the association of the polymorphism in Keywords: Epidemiology, Genetics Presenting author's disclosure statement:Qualified on the content I am responsible for because: research and education Any relevant financial relationships? No I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation. See more of: Genetic, Environmental and Molecular Epidemiology See more of: Epidemiology

Objective: To assess the relationship between b2 - adrenergic receptor (ADRB2) Arg16Gly polymorphism and metabolic syndrome (MS) in Japanese workers.

Method: In a retrospective cohort study, the participants of regular health examination in 1998 – 2006 on the Shimane Prefecture of Japan were examined the relationship between ADRB2 Arg16Gly polymorphism and MS. Covariates included sex, age, food balance, smoke, alcohol, exercise and sleeping - status. We constructed proportional hazards models of MS.

Results: A total of 865 participants were followed up for an average of 7.41 years. The allele frequencies of the 16Arg and 16Gly were 0.47 and 0.53, respectively. After multivariable adjustment, the hazard ratio of MS was 1.79 (95% confidence interval 1.06 – 3.00, p<0.03) among carriers of the 16Gly allele versus non – carriers. Conclusion: The ADRB2-16Gly allele may increase the risk of MS in this population.