203073 Cancer Genetics Network Ovarian Screening Study: Physician practice patterns in screening women at high risk for ovarian cancer: 2001 vs 2008

Monday, November 9, 2009

Heather L. Symecko, MPH , Biostatistics Center, Massachusetts General Hospital, Boston, MA
Dianne M. Finkelstein, PhD , Biostatistics Center, Harvard University, Boston, MA
Susan Domchek, MD , University of Pennsylvania, Philadelphia, PA
Judy E. Garber, MD, MPH , Dana-Farber Cancer Institute, Boston, MA
Carol H. Kasten, MD , Epidemiology and Genetics Research Program, National Cancer Institute, Bethesda, MD
Cancer Genetics Network (CGN) , c/o Data Coordinating Center for CGN, Massachusetts General Hospital, Boston, MA
Steven James Skates, PhD , Biostatistics Center, Harvard University, Boston, MA
The Cancer Genetics Network (CGN) began an Ovarian Cancer Screening Study in high-risk women in October 2001. The study utilizes longitudinal CA125 to screen healthy women with a family history of ovarian cancer using a statistical algorithm (ROCA: Risk of Ovarian Cancer Algorithm) to detect elevated or changing levels of serum CA125. The resulting calculated risk determined the study recommendation (re-test in 3 months, TVS, or referral to surgery). Preliminary searches failed to identify established guidelines for screening this population of women. To better understand how recruiting physicians were treating this population, a survey was designed to gather information on current practice patterns. The questionnaire included demographic information (age, sex, board certification), identification of tools used to classify a woman as high-risk, use of CA125 testing and transvaginal ultrasound (TVS) in screening, and use of prophylactic salpingo-oophorectomy (PSO) and hormone replacement therapy (HRT) in patient management. At study initiation, the survey was distributed to the participating centers. Nineteen Principal investigators and co-investigators from twelve of sixteen recruiting CGN academic genetics research centers participated. In order to determine if practice patterns have changed over the last seven years, a follow-up survey was distributed to the participating centers. To date, thirteen surveys, representing thirteen centers have been returned. A comparison of the respondents indicates they are the same cohort of physicians, based on median age, years in practice, and specialties reported. A detailed comparison of survey data from both time points will be presented to illustrate how practice has changed.

Learning Objectives:
Identify the factors used by physicians in screening women at high-risk for ovarian cancer. Compare practice patterns over the past seven years. Determine if differences in practice patterns differ by speciality (medicine versus gynecology).

Keywords: Cancer Screening, Physicians

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I have been the Project Manager for the Cancer Genetics Network (CGN)at Massachusetts General Hospital since 1998. I received my MPH from Yale University in 1996.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.

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