207366 Mammographic Density in African American, Caribbean and Caucasian Women

Tuesday, November 10, 2009: 12:50 PM

Parisa Tehranifar, DrPH , Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY
Julie Flom, MPH , Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY
Mary Beth Terry, PhD , Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY
Breast cancer risk and prevalence of many breast cancer risk factors vary by ethnicity and acculturation, but it is unclear whether similar variations exist for mammographic breast density, an intermediate marker of breast cancer. We examined ethnic variation in mammographic density in 168 women without a history of breast cancer, undergoing screening mammography (average age = 50.2). The sample consisted of 22% non-Hispanic Caucasian, 44% non-Hispanic African American, 23% Afro-Caribbean, and 10% Caribbean Hispanic. We used generational status as a proxy for acculturation as follows: U.S-born (U.S.-born participants with U.S.-born parents), 2nd generation (U.S.-born participants with foreign-born parents), 1st generation (foreign-born participants). We digitized mammograms and evaluated the proportion of dense area (in percentage) using a computer software. We used multivariable linear regression model to investigate the associations of percent density with race/ethnicity, generational status, current body mass index (BMI, kg/m2) and age. Age and BMI were significantly inversely associated with percent density (p< 0.001), with percent density being more than twice higher in normal weight (BMI<25) than in obese women (BMI≥30). As compared with African Americans, all other ethnic groups had lower percent density after adjusting for age and BMI, but these differences were not statistically significant. Generational status was not associated with density in the overall sample or among Caribbean women only. In conclusion, we did not observe significant influences on mammographic density by ethnicity and generational status in an urban multiethnic sample.

Learning Objectives:
1) Describe current literature on ethnic variation in mammographic density and associations with breast cancer risk factors 2) Compare associations between breast cancer risk factors and mammographic density across 4 ethnic groups 3)Discuss how acculturation may influence breast cancer risk and mammographic density

Keywords: Breast Cancer, Mammography

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I collaborated on developing research question, statistical analyses and interpretation of results.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.

See more of: Cancer Epidemiology
See more of: Epidemiology