211319 Evaluation of the impact of rotavirus vaccine on acute care visits, hospitalizations and laboratory testing in Wisconsin, 2002-2008

Tuesday, November 10, 2009: 1:15 PM

Stephanie L. Schauer, PhD , Bureau of Communicable Diseases, Wisconsin Division of Public Health, Madison, WI
Richard T. Heffernan, MPH , Bureau of Communicable Diseases, Wisconsin Division of Public Health, Madison, WI
Jonathan L. Temte, MD/PhD , Department of Family Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI
Carol J. Kirk , Wisconsin State Laboratory of Hygiene, Madison, WI
Peter Shult, PhD , Wisconsin State Laboratory of Hygiene, Madison, WI
Thomas R. Maerz , Bureau of Communicable Diseases, Wisconsin Division of Public Health, Madison, WI
Jeffrey P. Davis, MD , Bureau of Communicable Diseases, Wisconsin Division of Public Health, Madison, WI
Rotavirus is a highly communicable virus and the most common cause of severe gastroenteritis among infants and young children in the United States. In February 2006, a new rotavirus vaccine was licensed, and in August 2006 the Advisory Committee on Immunization Practices recommended its routine use in infants. Additionally, a second rotavirus vaccine was licensed in April 2008. To assess the uptake of rotavirus vaccine and evaluate its effect on rotavirus morbidity throughout Wisconsin we analyzed data from the following sources: the population-based Wisconsin Immunization Registry, a statewide hospital inpatient surveillance system, a network of outpatient clinics with 2.4 million outpatient visits during 2002 through 2008, and a network of up to 27 testing sites. By March 2008, 63% of children aged less than 12 months had received the complete series of 3 doses of rotavirus vaccine. Rotavirus hospitalizations (ICD-9=008.61) during January –June 2008 decreased from an annual mean of 418 during 2002-2006 to 66 in 2008 (84% decline). Acute care visits for all-cause diarrheal illness among children aged less than 12 months decreased by 50% in 2008 compared to 2006. While the average number of rotavirus tests conducted weekly has remained relatively constant from 2005 through 2008, the percentage of tests positive for rotavirus decreased by nearly two thirds. The brisk uptake of rotavirus vaccine among Wisconsin's infants appears to have significantly impacted rotavirus morbidity during the first two seasons following licensure of the new vaccines.

Learning Objectives:
Demonstrate the use of an IIS to determine state and regional vaccination coverage for the newly introduced rotavirus vaccines. Discuss changes in hospitalizations and laboratory testing since introduction of the rotavirus vaccines in 2006 and 2008.

Keywords: Immunizations, Rotavirus

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am employed full-time as an epidemiologist with the Wisconsin Department of Health Services, Division of Public Health working on the Wisconsin Immunization Information System. I earned a Ph.D. from Boston University School of Medicine in Microbiology/Immunology. Other relevant experience includes a post-doctoral fellowship in virology at Harvard Medical School, and have worked as an epidemiologist for the Massachusetts Department of Public Health, Immunization program. I have 16 publications in peer-reviewed journals and have served as a presenter and facilitator at local, state and national conferences.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.