217383 Translating genomic research on thrombophilia at CDC Office of Public Health Genomics

Sunday, November 7, 2010

William D. Dotson, PhD , Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA
Daurice A. Grossniklaus, RN, MEd, PhD , Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA
Marta Gwinn, MD, MPH , Office of Public Health Genomics, McKing Consulting Corp., Atlanta, GA
Michele Reyes, PhD, MS , Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA
Nicole F. Dowling, PhD , Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA
The Office of Public Health Genomics (OPHG) at CDC promotes the integration of genomics in research, practice and policy, and translational research that spans the continuum from gene discovery through population health impact. Within the field of blood disorders, OPHG has supported several projects that address genetic testing for factor V Leiden and prothrombin G20210A mutations. The international HuGENet collaboration, which was established by OPHG, has developed a relevant case-study on factor V Leiden and venous thrombosis. An evidence-based report on venous thromboembolism, including assessment of factor V Leiden and prothrombin G20210A genetic testing, was developed and released through the ACCE model project. In 2009, an OPHG supported evidence-based review on genetic testing for factor V Leiden and prothrombin G20210A was published by investigators at Johns Hopkins University AHRQ Evidence-based Practice Center. This report is intended to serve as the basis for development of an evidence-based recommendation statement by the independent EGAPP Working Group. The emerging GAPPNet enterprise should facilitate the identification of relevant gaps in knowledge through support of additional, and potentially broader, translational research on blood disorders.

Learning Areas:
Clinical medicine applied in public health
Other professions or practice related to public health

Learning Objectives:
Learners will be able to describe basic aspects of translational research in genomics.

Keywords: Genetics, Chronic Diseases

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am a health scientist at CDC Office of Public Health Genomics, working on activities supporting translational research in genomics.
Any relevant financial relationships? Yes

Name of Organization Clinical/Research Area Type of relationship
Novo Nordisk, Inc. Hemostasis Stock Ownership

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.