221282 Cancer incidence of the Residents from the Three Mile Island Accident Area

Sunday, November 7, 2010

Yueh Ying Han , Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA
Ada Youk, PhD , Department of Statistics, University of Pittsburgh, Pittsburgh, PA
Evelyn O. Talbott, DrPH, MPH , Department of Epidemiology, Director University of Pittsburgh Academic Center for Excellence in Environmental PH Tracking, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA
We report cancer risk associated with low-level radiation exposure from the March 28, 1979 Three Mile Island (TMI) accident.

The Pennsylvania Department of Health (PaDoH) established the TMI cohort by enrolling and interviewing all those present the day of the accident within a 5-mile radius. A total of 11,115 adult men and 11,770 women from TMI cohort were included. Cancer incidence data was available from 1982 to 1995 through the PaDoH cancer registry. Cox regression model was used to calculate relative risk (RR) and 95% confidence interval (95% CI) to assess incidence in four cancer sites: all malignant neoplasms (AMN), bronchus, trachea, and lung (BTL), lymph and hematopoietic tissue (LHT), and female breast associated with radiation-related exposures (background, maximum gamma, and likely gamma).

Adjusted for age, background radiation and smoking, men exposed to maximum gamma 8-19 mrem had increased risk of AMN compared to those exposed to <8 mrem (RR=1.23, 95% CI=1.00-1.52). Among women, higher likely gamma exposure increased risk for AMN (RR=1.00, 1.36, 1.41, and 1.24 for 3, 3-7, 8-15, and 16+ mrem, respectively, P=0.01). Increased female breast cancer risk was associated with likely gamma exposure (RR=1.00, 1.83, 1.88, and 1.64 for 3, 3-7, 8-15, and 16+ mrem, respectively, P<0.01) adjusted for age, education and background radiation. No relationship was found between radiation exposure and cancer incidence of BTL and LHT.

Potential increased cancer risks from low-level radiation exposure within TMI cohort can not be excluded. Information on an updated period for this group would be an important goal for future research.

Learning Areas:
Environmental health sciences
Public health or related research

Learning Objectives:
Evaluate cancer risk associated with low-level radiation exposure from Three Mile Island (TMI) accident occurred on 28 March l979, Pennsylvania

Keywords: Cancer, Radiation

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am qualified to present becuase I analyzed the data, and write up the manuscript of this work. PI of this study also authorized me to present this work.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.