222190 Correction of vitamin D inadequacy by food fortification

Monday, November 8, 2010 : 10:45 AM - 11:00 AM

Irina V. Haller, PhD, MS , Research Division, Essentia Institute of Rural Health, Duluth, MN
Diane Krueger, BS , Osteoporosis Research Program, University of Wisconsin, Madison, Madison, WI
Jean Engelke , Osteoporosis Research Program, University of Wisconsin, Madison, Madison, WI
Neil Binkley, MD , Osteoporosis Research Program, University of Wisconsin, Madison, Madison, WI
Food fortification with vitamin D exceeding currently utilized amounts is a logical approach to improve vitamin D status at the population level. Methods – This randomized double-blind trial examined serum 25-hydroxyvitamin D [25(OH)D] response to daily ingestion of a low calorie chocolate disk with ~2,200 IU of vitamin D3 or placebo (PBO) for 4 months in women aged 20-30 years (n=31), 55-65 years (n=34) and 75+ years (n=34). All participants had 24-hour urinary calcium, serum calcium and serum 25(OH)D measured at baseline and months 1, 2 and 4. Data were analyzed using general linear model by age and treatment group adjusted for baseline 25(OH)D levels and BMI. Results – Baseline mean 25(OH)D levels did not differ between D3 or PBO groups with the overall mean±SE equal 29.5±1.1 ng/ml. At baseline, 45% had suboptimal vitamin D status, defined as a 25(OH)D concentration < 30 ng/ml, with greater proportion (52%) among postmenopausal women compared to younger (27%) women (p<0.05). The 25(OH)D concentration increase at month 4 was 14.1 ng/ml in women receiving vitamin D fortified food, however 11% remained below 30 ng/ml. Serum and 24-hour urinary calcium were unaffected by intake of vitamin D fortified food. Age-group effect on the 25(OH)D increase was insignificant. Conclusion – Food fortification with 2,200 IU of vitamin D3 is safe, effective and increases serum 25(OH)D levels similar to supplements. The daily vitamin D requirement likely exceeds 2,200 IU to assure optimal levels for all women, especially for those who are 55 years or older.

Learning Areas:
Public health or related research

Learning Objectives:
1. Describe the effect of vitamin D fortified food on vitamin D status 2. Compare vitamin D status in older and younger adults

Keywords: Women's Health, Nutrition

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am qualified to present because I am co-PI on the research study "Vitamin D Inadequacy: Documentation in Rural Populations and Evaluation of Correction by Food Supplementation".
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.