238231 Methods to model and characterize person-level features of the salivary cortisol profile in population research—The Multi Ethnic Study of Atherosclerosis

Monday, October 31, 2011: 10:30 AM

Brisa N. Sanchez, PhD , Department of Biostatistics, University of Michigan, Ann Arbor, MI
Trivellore Raghunathan, PhD , Department of Biostatistics, University of Michigan, Ann Arbor, MI
Ana V. Diez-Roux, PhD, MD , Department of Epidemiology, University of Michigan, Ann Arbor, MI
Meihua Wu, MS , Department of Biostatistics, University of Michigan, Ann Arbor, MI
Many studies have hypothesized that stress and its biological consequences may contribute to disparities in cardiovascular disease. However, our understanding of the most appropriate statistical methods useful to analyze biological markers of stress such as salivary cortisol remains limited. We explore the utility of various statistical methods in modeling the stress response curve, as well as characterizing features of stress response in population based studies. In addition to commonly used summaries such as the cortisol awakening response and the area under the curve, we also propose alternative curve features. We compare the inference and interpretations drawn from these methods, and use data collected as part of the Multi-Ethnic Study of Artherosclerosis (MESA) to illustrate them.

Learning Areas:
Biostatistics, economics
Social and behavioral sciences

Learning Objectives:
Describe approaches to model salivary cortisol in epidemiological studies

Keywords: Statistics, Stress

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am qualified to present because I am the first author of the manuscript associated with this presentation.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.