241117 Effect of Caloric Restriction and Protein Intake on Insulin-like growth factor and Insulin-like growth factor binding protein-3

Tuesday, November 1, 2011: 9:00 AM

Aakruti Bhalja, BA , New York College of Podiatric Medicine, New York, NY
Anthony Iorio, DPM, MPH, FACFAS, FACFAOM, CPED, FACWCA , Department of Community Health, New York College of Podiatric Medicine, New York, NY
Previous studies have shown that dietary protein is important for bone health. In addition insulin like growth factor and IGF-binding protein-3 are essential for bone growth and maintenance. Weight loss due to normal caloric restriction can result in a decrease in IGF-1/IGF-binding protein which can have an adverse effect on bone health. The aim of this study was to determine whether IGF-1 and binding protein-3 is associated with lean body mass, bone mass and turnover in overweight and obese postmenopausal women and whether it is altered by the level of dietary protein intake during caloric restriction. It is hypothesized that a high protein diet (HP) compared to a normal protein (NP) diet will prevent a decline in serum IGF-1/binding proteins, normally associated with caloric restriction. In this year- long study postmenopausal women were recruited for weight loss and instructed to follow a reduced calorie, well balanced diet. Participants were placed randomly on either a low-calorie NP or HP diet and consumed the recommended level of calcium and vitamin D. In this analysis, we measured serum IGF-1, IGFBP-3 and body composition (fat, muscle mass, and bone mineral density and content) using dual energy x-ray absorptiometry. Recent research indicates that an increased body mass index is related to greater risk of ankle fracture. A large population of overweight, postmenopausal women would benefit from this study because protein would compensate for weight loss related-reduction in bone mass and would diminish the risk of ankle fracture occurrence.

Learning Areas:
Chronic disease management and prevention
Public health biology

Learning Objectives:
Evaluate the applicability of advising high protein intake during caloric restriction in order to attenuate a decrease in bone mass and effectively reduce the occurrence of ankle fracture.

Keywords: Nutrition, Obesity

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I have worked collaboratively with others in performing extensive research in the areas of nutrition and bone in attempt to improve lower extremity care in the community.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.