241365 Influence of high sensitivity C-reactive protein on pulsatile arterial function in asymptomatic younger adult : The Bogalusa Heart Study

Sunday, October 30, 2011

Azad R. Bhuiyan, MD, PhD , Department of Epidemiology, Jackson State University, Jackson, MS
Background: Low grade systemic inflammation depicted by high sensitivity C-reactive protein (hs-CRP) has emerged as an independent predictor of cardiovascular (CV) disease and type 2 diabetes. Impaired pulsatile arterial function is also an independent predictor of early vascular damage and related CV outcome. However, information linking hs- CRP and pulsatile arterial function in a community-based cohort is scant. Methods: This aspect was examined in a cohort of 599 black and white subjects (27 % black, 42 % male) aged 26-43 years (mean 37.6 years) enrolled in the Bogalusa Heart Study. Pulsatile arterial function was assessed in terms of large artery compliance and small artery compliance by noninvasive radial artery pressure pulse contour analysis.

Results: Females vs. males had significantly higher CRP level (2.89 mg/L vs. 1.99 mg/L, p=0.0004). Large artery compliance was lower in blacks vs. whites (14.25 ml/mmHg vs. 15.54 ml/mmHg, p 0.0003) as well as females vs. males (13.86 ml/mmHg vs. 15.92 ml/mmHg, P< 0.0001). In a multivariate regression model, adjusting for race, sex, age, body surface area, cardiac output, triglycerides/ HDL cholesterol ratio hs-CRP remained independently and inversely associated with large artery compliance.

Conclusions: The observed deleterious effect of hs-CRP on large artery compliance in asymptomatic younger adults underscores the utility of hs-CRP as a biomarker of CV risk.

Learning Areas:
Chronic disease management and prevention

Learning Objectives:
Demonstrate the utility of C-reactive protein as a biomarker of CV risk in young adults

Keywords: Chronic (CVD), Risk Assessment

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: As a faculty I involved in teaching and research in Jackson State University, MS, USA
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.