243503 Association between Serum Perfluorinated Chemicals and Attention Deficit Hyperactivity Disorder in US School-age Children

Tuesday, November 1, 2011: 1:20 PM

Xiaohui Xu , Department of Epidemiology & Biostatistics, College of Public Health and Health Professions, University of Florida, Gainesville, FL
The wide detection of perfluorinated chemicals (PFCs) in environment, wildlife and human has raised increasing concerns about the neurotoxicity of these chemicals. Experimental studies have shown their developmental neurotoxicity in several animal species. However, epidemiological evidence on their developmental neurotoxicity remains very limited. In this study, we used the 1999-2000 and 2003-2004 National Health and Nutrition Examination Survey to examine associations between serum concentrations of PFCs and attention deficit hyperactivity disorder (ADHD) among children aged 12-19 years old (N=1,190). After adjusting for covariates including demographic factors, blood cotinine, and blood lead, exposure to the highest level of perfluorooctane sulfonic acid was significantly associated with ADHD as compared with the lowest level(OR=3.04, 95%CI: 1.10-8.42 in the 2nd tertile, OR=4.07, 95%CI: 1.73-9.58 in the 3rd tertile, P for trend=0.001). The finding indicates that perfluorinated chemicals may play a role in the neurodevelopment of the US children. While our results reinforce the findings from the experimental studies, further study in a longitudinal sample is warranted.

Learning Areas:
Environmental health sciences

Learning Objectives:
evaulate if body burden of perfluorinated chemicals (PFCs) is associated with the prevalence of attention deficit hyperactivity disorder (ADHD) among school-age children in the USA.

Keywords: Environmental Exposures, Child/Adolescent Mental Health

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am qualified to present because I oversee the project.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.

See more of: Environmental Epidemiology
See more of: Epidemiology