248111 High birth weight and childhood asthma: A meta-analysis and systematic review

Sunday, October 30, 2011

Neha Upadhyay, MBBS , MPHc , Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL
Angelico Mendy, MD, MPH , Department of Epidemiology, Florida International University, Miami
Janvier Gasana, MD PhD , Environmental & Occupational Health, FIU Stempel College of Public Health and Social Work, Miami, FL
Background In the last 20 years Asthma and Obesity have increased concomitantly in westerns countries. Both Asthma and Obesity are major public health issues that stem from childhood. Research has also indicated obesity as a factor in the development of childhood asthma due to an increase in cytokine causing a bronchial hyper responsiveness; this compounded with the mechanical complications complement the pathophysiology of Bronchial Asthma. . The aim of this study is to analyse the effect of high body weight at birth on the future risk of asthma, as both asthma and obesity stem from foetal and early childhood stages.

Methods We performed a literature search using PubMed, Highwire, and The Cochrane Library, using the keywords ‘high birth weight', and ‘asthma', ‘children' up to February 2011. Adjusted effect sizes on odds of asthma in children with high birth weight or ponderal index were pooled by mean of weighted average to generate pooled summary fixed or random estimates, depending on Cochran Q heterogeneity test.

Results On a set of five consistent studies included in our meta-analysis (Cochran Q test p value = 0.69, I2 null), high birth weight was not found to be associated with asthma in children (fixed – effect meta OR: 0.92, 95% CI: 0.83, 1.02).

Conclusions Our study suggests that high birth weight is unrelated to childhood asthma. More generally, birth weight may not play a role in the development of asthma, since Other research that reported a probable association with low weight were confounded by prematurity.

Learning Areas:
Biostatistics, economics
Public health biology

Learning Objectives:
Define childhood asthma List the various etiologies of childhood asthma Describe the etiopathogenesis of asthma Explain how obesity can complicate childhood asthma Identify Risk Factors for asthma Compare Low birth Weight and High birth weight as etiologies for asthma

Keywords: Children and Adolescents, Obesity

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am qualified to present as I have worked in the Department of Pediatrics as a Medical Officer
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.