248867 Age of Sexual Debut and Risk of Cervical Cancer: A meta-analysis

Monday, October 31, 2011

Bertha Hidalgo, MPH , Epidemiology, University of Alabama at Birmingham, Birmingham, AL
Tiffany L. Cox, PhD, MPH , Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR
Rikki Tanner, MPH , Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL
Cervical cancer is the second most commonly diagnosed cancer and the third leading cause of death among women worldwide. Age at sexual debut along with number of sexual partners has been established as potential risk factors for cervical cancer. However, studies have been limited in specifically assessing whether age of sexual debut can predict time to cervical cancer onset. In this Meta analysis, we reviewed the published literature for age of sexual debut and risk of cervical cancer. 6 case-control studies were identified through mesh term searches of Pubmed and Medline. All 6 studies showed that women are at risk for cervical cancer at a younger age if age at sexual debut occurs early on. Results from a fixed effects Meta analysis gave a pooled risk estimate of 3.4 (95% CI: 2.9-3.9). A test for heterogeneity suggested that variability was low enough that a random effects model was not necessary (q2=14.8). Our findings are consistent with a recently published pooled analysis demonstrating that the risk for cervical cancer increased with earlier age at intercourse. Our study shows that early age of sexual debut may be predictive of early age at cervical cancer onset.

Learning Areas:
Public health or related research

Learning Objectives:
This abstract will describe results found in a compilation of peer-reviewed published articles regarding the association between age at sexual debut and risk of cervical cancer.

Keywords: Cancer Prevention, Cervical Cancer

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am a graduate student in Epidemiology with specific interest in cervical cancer, as well as in general cancer prevention and control.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.