249109 Systemic inflammation changes following fish oil supplementation

Monday, October 31, 2011: 1:30 PM

Rodney G. Bowden, PhD , School of Education, Baylor University, Waco, TX
Erika Deike, PhD , Human Peformance, Wayland Baptist University, Planview, TX
Jen Moreillon, PhD , Hhpr, Baylor University, Waco, TX
Jackson Griggs, MD , Family Health Center, Waco, TX
Ronald L. Wilson, MD , Central Texas Nephrology Associates, Waco, TX
Brian Shelmadine, PhD , Hhpr, Baylor University, Waco, TX
A. Alexander Beaujean, PhD, PhD , Department of Educational Psychology, Baylor University, Waco, TX
Introduction: Omega-3 fatty acids [n-3] have been used in previous studies to control inflammatory markers with equivocal findings. Methods: This study was conducted using a double-blind, permuted-block-randomized and placebo controlled experimental design. End-Stage-Renal Disease (ESRD) patients (N=31) were followed prospectively for 2-months while supplementing their diet with either six grams of n-3 or corn oil (placebo [n-6]). Results: Cox proportional-hazards regression model revealed no significant differences between the groups concerning age, months on dialysis, diabetes, ethnicity, and tobacco history. ANCOVA that controlled for the covariate of compliance revealed a significant difference in the inflammatory marker of TNF-alpha with higher posttest levels in the n-3 group (p=.025). Though clinical differences were evident, there were no significant differences in other inflammatory markers of IL-1beta (p=.816) and IL-6 (p=.584). Conclusions: Supplementing n-3 in the diet did not change the cardiovascular risk profile of patients with elevated inflammation. The protective effects that have occurred in other studies are primarily due to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) found in n-3, which has been linked to reduced cardiovascular morbidity and mortality. It has recently been discovered that inflammation plays a significant role in cardiovascular mortality with novel approaches needed for ESRD patients. Yet, inflammation was lowered in the control group (TNF-alpha) suggesting n-6 may help to lower systemic inflammation in a chronic disease population but not n-3.

Learning Areas:
Basic medical science applied in public health
Chronic disease management and prevention
Clinical medicine applied in public health

Learning Objectives:
1. Describe the benefits of using fish oil supplementation in their diet 2. Analyze the differences in omega-3 and omega-6 oils 3. Differentiate between inflammatory markers

Keywords: Epidemiology, Alternative Medicine/Therapies

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am the PI for this study
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.