250421 Parental exposures and risk for childhood acute lymphoblastic leukemia, Colombia, 2000-2005

Monday, October 31, 2011

Miguel Castro-Jiménez, MD, MSc , Programa Maestría en Epidemiología, Departamento Salud Pública, Escuela de Medicina, Universidad Industrial de Santander, Grupo Colombiano de Estudios Alfa en Epidemiología, Salud Poblacional, Estadística Aplicada y Ciencias Aliadas, Bucaramanga, Colombia
Luis Orozco-Vargas, MD, MSc , Escuela de Enfermería, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia
Objective: The objective of this paper is to determine the risk factors for childhood acute lymphoblastic leukemia (ALL) and, in particular, the role of the parental occupational exposure to carcinogenic and probably carcinogenic hydrocarbons before the child's conception. Methods: We conducted a neighborhood-based matched case-control study in six Colombian hospitals. Cases were children (0-14 years) who were newly diagnosed with ALL between January, 2000 and March, 2005. An interview with both parents of 170 children (85 cases and 85 individually matched neighborhood controls) gathered information about parental demographic and occupational characteristics, medical history, habits, pregnancy and birth history and child's exposures. A job-exposure matrix was used. Conditional odds ratios (OR) and 95% confidence intervals (95%CI) were calculated by period of exposure (preconception, pregnancy and childhood). Results: The risk of childhood ALL was linked to: a. parental occupational exposure to hydrocarbons before conception: neither parent exposed (reference); father only (OR=1.66; 95%CI: 0.64-4.28); mother only (OR=6.33; 95%CI: 1.41-28.31); both exposed (OR=13.47; 95%CI: 3.31-54.71); b. paternal and/or maternal smoking before conception (OR=2.63; 95%CI: 1.24-5.56); c. maternal low socioeconomic status during pregnancy (OR=3.53; 95%CI: 1.22-10.21) and; d. advanced maternal age at birth (35+: OR=3.72; 95%CI: 1.13-12.29). Conclusions: These findings suggest an association between childhood ALL and the parental occupational exposure to carcinogenic and probably carcinogenic hydrocarbons before conception showing differences depending on the parent exposed, however, in further studies, the additive or multiplicative role of other environmental sources of hydrocarbons should also be investigated.

Learning Areas:
Chronic disease management and prevention
Clinical medicine applied in public health
Occupational health and safety
Public health or related research

Learning Objectives:
To evaluate the role of the parental occupational and non-occupational exposures on the risk of childhood lymphoblastic leukemia.

Keywords: Risk Factors, Cancer

Presenting author's disclosure statement:

Qualified on the content I am responsible for because: I am a medical doctor with a Master Degree in Epidemiology. I proposed this work as my Master's thesis and I participated in each of the different stages beginning by its conception. Recently a first paper was accepted for the editorial commitee of an important american journal in chronic diseases.
Any relevant financial relationships? No

I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.